Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdrl gene and cross-resistance to halofantrine
Evaluation of biochemical indices following administration of artemether, halofantrine
and a combination of artemether and lumefantrine in guinea pigs.
Anti-infection drugs: Erythromycin, Halofantrine
, Maraviroc, Primaquine, Quinine, Rilpivirine
Antimalarial drug resistance has spread and intensified over the last 15-20 years, leading to a dramatic decline in the efficacy of most antimalarial drugs including aminoquinolines, halofantrine
, sulfadoxine-pyrimehtamine etc [6,10,76,50,55].
falciparum malaria; halofantrine
is not recommended.
Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine
Drug discovery (1970s): Halofantrine
, discovered and developed at SRI, has saved countless lives as a treatment for drug-resistant malaria.
Several antimicrobial agents, such as erythromycin, clarithromycin, fluoroquinolones, halofantrine
and pentamidine can cause QT prolongation.
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
was approved by the FDA as an anti-malarial drug.
Some serum and tissue enzyme changes in mice infected with Plasmodium yoelli nigeriensis before and after administration of halofantrine
treatment is not advisable given the associated cardiotoxicity, variable bioavailability and drug interactions in patients who have taken mefloquine prophylaxis.