halofantrine


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halofantrine

 [-fan´trēn]
an antimalarial agent used as the hydrochloride salt in treatment of acute malaria due to Plasmodium falciparum or P. vivax.

halofantrine

/hal·o·fan·trine/ (-fan´trēn) an antimalarial used as the hydrochloride salt in the treatment of acute malaria due to Plasmodium falciparum and P. vivax.

halofantrine

an antimalarial.
indication It is used to treat mild to moderate malaria.
contraindication Known hypersensitivity to halofantrine prohibits its use.
adverse effects Common side effects include nausea, vomiting, anorexia, diarrhea, and arrhythmias.

halofantrine

A phenanthrene anti-malarial drug used to treat both main types of malaria, those caused by Plasmodium falciparum and Plasmodium vivax . A brand name is Halfan.
References in periodicals archive ?
Decreasingpfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
20) These HPLC methods were used to characterize the pharmacokinetic-pharmacodynamic interaction of mefloquine in resistant P falciparum malaria on the Thai-Burma/Myanmar ** border, (21) assess the efficacy of halofantrine in treating Thai patients who failed mefloquine chemoprophylaxis, (22) evaluate the potential of ciprofloxacin in treating drug-resistant falciparum malaria, (23) assess the effect of food on the disposition of halofantrine in treating falciparum malaria (24) and determine the effectiveness of high-dose mefloquine in treating multidrugresistant falciparum malaria.
Nnadi, "Development and validation of novel hydrotropic solubilization method for spectrophotometric determination of halofantrine in pure and solid dosage form," Scholar's Academic Journal of Pharmacy, vol.
Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.
Evaluation of biochemical indices following administration of artemether, halofantrine and a combination of artemether and lumefantrine in guinea pigs.
However, in 1993, reports of severe and sometimes fatal cardiotoxicity associated with the use of halofantrine led the World Health 8 Organization to limit its use , and as of 2002, there were at least 20 reports of fatal cardiac 9 complications relating to use of the drug .
Anti-infection drugs: Erythromycin, Halofantrine, Maraviroc, Primaquine, Quinine, Rilpivirine
Examination of oral absorption and lymphatic transport of halofantrine in a triplec-annulated canine model after administration in selfmicroemulsifying drug delivery systems containing structured triglycerides.
A number of antimalarial drugs have been implicated in infertility: halofantrine hydrochloride caused reduction in follicle size and cytoplasmic vacuolation in the ovary of the rats (Adjene and Agoreyo, 2003); chloroquine altered the oestrus cycle, lowered serum oestrogen, and LH levels, while serum FSH was unaltered and prevented the expected ovulation (Okanlawon and Ashiru, 1992); sperm motility as well as sperm counts were significantly decreased in pyrimethamine (PYR)-treated animals, and the fertility rate fell to zero (Kalla et al.
Lengthening of the QTc and severe cardiac arrhythmia has been observed, particularly after treatment with halofantrine for chloroquine resistant Plasmodium falciparum malaria (11).
Antimalarial drug resistance has spread and intensified over the last 15-20 years, leading to a dramatic decline in the efficacy of most antimalarial drugs including aminoquinolines, halofantrine, sulfadoxine-pyrimehtamine etc [6,10,76,50,55].