halofantrine


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halofantrine

 [-fan´trēn]
an antimalarial agent used as the hydrochloride salt in treatment of acute malaria due to Plasmodium falciparum or P. vivax.

halofantrine

/hal·o·fan·trine/ (-fan´trēn) an antimalarial used as the hydrochloride salt in the treatment of acute malaria due to Plasmodium falciparum and P. vivax.

halofantrine

an antimalarial.
indication It is used to treat mild to moderate malaria.
contraindication Known hypersensitivity to halofantrine prohibits its use.
adverse effects Common side effects include nausea, vomiting, anorexia, diarrhea, and arrhythmias.

halofantrine

A phenanthrene anti-malarial drug used to treat both main types of malaria, those caused by Plasmodium falciparum and Plasmodium vivax . A brand name is Halfan.
References in periodicals archive ?
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdrl gene and cross-resistance to halofantrine and quinine.
Evaluation of biochemical indices following administration of artemether, halofantrine and a combination of artemether and lumefantrine in guinea pigs.
Anti-infection drugs: Erythromycin, Halofantrine, Maraviroc, Primaquine, Quinine, Rilpivirine
Antimalarial drug resistance has spread and intensified over the last 15-20 years, leading to a dramatic decline in the efficacy of most antimalarial drugs including aminoquinolines, halofantrine, sulfadoxine-pyrimehtamine etc [6,10,76,50,55].
falciparum malaria; halofantrine is not recommended.
Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.
Drug discovery (1970s): Halofantrine, discovered and developed at SRI, has saved countless lives as a treatment for drug-resistant malaria.
Several antimicrobial agents, such as erythromycin, clarithromycin, fluoroquinolones, halofantrine and pentamidine can cause QT prolongation.
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine.
2002: Halofantrine was approved by the FDA as an anti-malarial drug.
Some serum and tissue enzyme changes in mice infected with Plasmodium yoelli nigeriensis before and after administration of halofantrine hydrochloride.
12) Halofantrine treatment is not advisable given the associated cardiotoxicity, variable bioavailability and drug interactions in patients who have taken mefloquine prophylaxis.