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hairy-cell leukemia

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hairy-cell leukemia
Etymology: AS, haer + L, cella, storeroom; Gk, leukos, white, haima, blood
an uncommon neoplasm of blood-forming tissues, characterized by pancytopenia, enlargement of the spleen, and many fine projections on the surface of reticulum cells in the blood and bone marrow. The disease occurs six times more frequently in men than in women and usually appears in the fifth decade with an insidious onset and a variable course marked by anemia, thrombocytopenia, and spontaneous bruising. Some cases may achieve long-term remission through alpha-interferon administration or chemotherapy using vincristine and prednisone. Also called leukemic reticuloendotheliosis.


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10403W) cited the firm's reprint carrier and journal ad for Nipent (pentostatin), a treat-ment for untreated and alpha-interferon-refractory hairy-cell leukemia, for claims of a 67% ten-year relapse-free survival rate and an 81% ten-year overall survival rate that were "derived from the Finn study (which) are not sup-ported by sub-stantial evidence.
They tell the story of John Moore, a Seattle businessman, who fell ill with hairy-cell leukemia and went to a specialist at the UCLA School of Medicine.
Cladribine (2-CdA, commonly known by its brand name Leustatin) is also already in use to treat hairy-cell leukemia.
 
 
 
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