hairy leukoplakia


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to hairy leukoplakia: lichen planus, Kaposi Sarcoma, Oral candidiasis

hair·y leu·ko·pla·ki·a

a white lesion appearing on the tongue, occasionally on the buccal mucosa, of patients with AIDS; a manifestation of Epstein-Barr virus infection in an immunocompromised host. The lesion appears raised, with a corrugated, shaggy, or "hairy" surface due to keratin projections.

hairy leukoplakia

a form of leukoplakia characterized by a white plaque that is markedly folded in appearance or smooth and is often visible on one or both lateral borders of the tongue. It is associated with severe immunodeficiency, occurs in human immunodeficiency virus-infected patients, and is believed to result from the Epstein-Barr virus. It has a high correlation with progression from herpes zoster virus infection to AIDS.
enlarge picture
Hairy leukoplakia
An Epstein-Barr-associated condition seen in HIV infection, which is characterised by a condyloma-like tongue mass—75% of patients have HPV, 95% have EBV—in epithelial cell nuclei preceding the onset of clinical AIDS

hairy leukoplakia

Oral pathology An EBV-associated condition seen in HIV infection, characterized by a condyloma-like tongue mass–75% have HPV, 95% have EBV in epithelial cell nuclei preceding clinical AIDS. See AIDS.

hair·y leu·ko·pla·ki·a

(hār'ē lū'kō-plā'kē-ă)
A white lesion appearing on the tongue or buccal mucosa of immunocompromised patients; the lesion appears raised, with a corrugated or "hairy" surface. Seen in patients with HIV/AIDS, it has been associated with Epstein-Barr virus. Condition is usually benign and subsides with therapy.
See also: leukoplakia

hair·y leu·ko·pla·ki·a

(hār'ē lū'kō-plā'kē-ă)
White raised lesion seen on tongue, occasionally on buccal mucosa, in an immunocompromised host.
References in periodicals archive ?
1999] found that either Oral Hairy Leukoplakia or Oral Candidiasis were 1.
Oral candidosis and oral hairy leukoplakia as predictors of HAART failure in Brazilian HIV-infected patients.
Late last year, the California researchers reported that hairy leukoplakia is also a sign of AIDS in high-risk groups other than homosexual men.
The gross appearance of the hairy leukoplakia lesion may be variable, resulting in possible misdiagnosis.
However, hairy leukoplakia lesions are commonly also infected with Candida, further confusing the clinical diagnosis.
The association of herpes zoster, oral candidiasis, oral hairy leukoplakia and molluscum contagiosum with HIV was so significant that these cutaneous conditions were used as signs of disease progression in early clinical trials of antiviral medications.
Molluscum contagiosum becomes easily manageable and candida and oral hairy leukoplakia clear.
Oral and dermatologic conditions commonly seen with HIV infection Herpes zoster in patients under 50 yr old New-onset psoriasis in patients over 30 yr old Oral candidiasis Oral hairy leukoplakia Recalcitrant vaginal candidiasis New onset of common warts on hands, feet, and beard area in adult Sexually transmitted disease (ie, syphilis, gonorrhea, herpes simplex, chancroid, human papillomavirus) Molluscum contagiosum in adult Numerous nails with fungal infection, especially fingernails Pruritus Petechiae or idiopathic thrombocytopenic purpura Viral exanthem Kaposi's sarcoma
They also had a 7%-10% lower rate of oral hairy leukoplakia than those not on such regimens; however, this rate did not achieve statistical significance.
Antiretroviral therapy-with and without protease inhibition-appears to protect against oral candidiasis and has no relationship to the occurrence of oral hairy leukoplakia.
While the development of new antiretroviral therapies for the management of HIV infection, particularly protease inhibitors, has resulted in a decreased prevalence of certain oral diseases such as hairy leukoplakia and necrotizing periodontitis, a paradoxical increase in oral warts has been observed.