| hairy leukoplakia n. A white raised lesion having keratin projections on its surface and appearing on the tongue and occasionally on the buccal mucosa of patients with AIDS. |
hairy leukoplakia,
a form of leukoplakia characterized by a white plaque that is markedly folded in appearance or smooth and is often visible on one or both lateral borders of the tongue. It is associated with severe immunodeficiency, occurs in human immunodeficiency virus-infected patients, and is believed to result from the Epstein-Barr virus. It has a high correlation with progression from herpes zoster virus infection to AIDS.
leukoplakia (loo´kōplā´kē
),n a white plaque formed on the oral mucosa from surface epithelial cells with an unknown etiology. It is leathery, opaque, and somewhat thickened. Excluded from this are the white lesions of lichen planus, white sponge nevus, burns, thrush, and other clinically recognizable entities. Histologically, hyperkeratosis, acanthosis, and subepithelial and perivascular infiltrate of round cells may be seen. Dyskeratosis may be present. These lesions may progress to malignancy, with cellular atypicism, dyskeratosis, epithelial pearl formation, and infiltration of malignant cells into connective tissue. See also dyskeratosis; hyperkeratosis.
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Leukoplakia.
leukoplakia, hairy,
n a white lesion appearing on the lateral surface of the tongue and occasionally on the buccal mucosa of patients with AIDS. The lesion appears raised, with a corrugated or “hairy” surface as a result of keratin projections.
hairy leukoplakia
Oral pathology An EBV-associated condition seen in HIV infection, characterized by a condyloma-like tongue mass–75% have HPV, 95% have EBV in epithelial cell nuclei preceding clinical AIDS. See AIDS.
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