A monocytopenia was present, but hairy cells were not described.
Hairy cell leukemia (HCL) is an indolent neoplasm composed of small mature B lymphocytes (1).
A blood smear showed 10% hairy cells, and a bone marrow biopsy confirmed a diagnosis of hairy cell leukemia and interstitial infiltration of CD20-positive, monoclonal antibody DBA.
We report 2 cases of melioidosis and hairy cell leukemia in travelers returning from Thailand.
Eight percent of type-5 TRAP from hairy cells was left in the 14G6 unbound fraction, whereas >90% of the RBC and platelet TRAP was unbound.
Antibody 14G6 was raised against purified TRAP from the spleens of patients with hairy cell leukemia.
Table 2 Selected flow cytometry panels and their objectives Antibody panel Objective CD5, CD19 CD10 Detects chronic lymphocytic leukemia CD20 CD11c, CD22 Detects B-cells or hairy cells CD33, CD13, HLADr Resolves myeloid leukemia cells CD7, CD1, CD2 Defines mature and immature T-cells subsets CD38, CD56, CD45 Resolves plasma and myeloma cells CD5 CD14 CD19 Defines T and B cells and monocytes in cerebral spinal fluid CD16 CD13, HLADr Defines acute promyelomonocytic leukemia CD71, CD3, CD4 Activation of T-helper/inducer cell subset CD20, CD79, CD22 Evaluation of CD79 to resolve certain B-cell malignancies CD33, UIC2, CD34 Evaluate drug resistance or progenitor cells Source: Roswell Park Cancer Institute
Stewart is working on a compendium of unique and generic patterns for some common diseases such as hairy cell leukemia, chronic myelogenous leukemia, and others that he will distribute to physicians.
Although the etiology of paraneoplastic vasculitis is not yet clearly known, suggested mechanisms are: (i) vascular damage caused by cross-reactions between antibodies against tumor cells and the vascular endothelium (ii) vascular inflammation caused by immune complexes involving tumor antigens (iii) direct vascular damage caused by the hairy cells in hairy cell leukemia.
14) It is mostly associated with hairy cell leukemia.
This fusion protein may also latch onto healthy B cells, killing some, but it proves more consistently lethal to the hairy cells
, which have more CD22 receptors, says Kreitman.
are observed in the peripheral blood in 90% of HCL patients.