hairy cells

hair·y cells

medium-sized leukocytes that have features of reticuloendothelial cells and multiple cytoplasmic projections (hairs) on the cell surface, but which may be a variety of B lymphocyte; they are found in hairy cell leukemia.
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The large arrows in Figure 2, A and B, indicate single double-positive hairy cells.
A recent publication regarding CD103 immunostaining on paraffin sections noted that CD103 is expressed in the cytoplasm of some normal bone marrow cells, suggesting that this cytoplasmic pattern allows normal cells to be distinguished from hairy cells characterized by membrane CD103 expression.
A blood smear showed 10% hairy cells, and a bone marrow biopsy confirmed a diagnosis of hairy cell leukemia and interstitial infiltration of CD20-positive, monoclonal antibody DBA.
We report 2 cases of melioidosis and hairy cell leukemia in travelers returning from Thailand.
An energetic exhaustion of the hairy cells is assumed as the physiological mechanism which causes the temporary threshold shift (TTS) as the first step towards a permanent hearing deficiency (permanent threshold shift, PTS).
Although the etiology of paraneoplastic vasculitis is not yet clearly known, suggested mechanisms are: (i) vascular damage caused by cross-reactions between antibodies against tumor cells and the vascular endothelium (ii) vascular inflammation caused by immune complexes involving tumor antigens (iii) direct vascular damage caused by the hairy cells in hairy cell leukemia.
This fusion protein may also latch onto healthy B cells, killing some, but it proves more consistently lethal to the hairy cells, which have more CD22 receptors, says Kreitman.
Eight percent of type-5 TRAP from hairy cells was left in the 14G6 unbound fraction, whereas >90% of the RBC and platelet TRAP was unbound.
Hairy cells are observed in the peripheral blood in 90% of HCL patients.
Typical hairy cells (Figure 1, B) have round to reniform nuclei without prominent nucleoli and with a moderate amount of pale cytoplasm.
Table 2 Selected flow cytometry panels and their objectives Antibody panel Objective CD5, CD19 CD10 Detects chronic lymphocytic leukemia CD20 CD11c, CD22 Detects B-cells or hairy cells CD33, CD13, HLADr Resolves myeloid leukemia cells CD7, CD1, CD2 Defines mature and immature T-cells subsets CD38, CD56, CD45 Resolves plasma and myeloma cells CD5 CD14 CD19 Defines T and B cells and monocytes in cerebral spinal fluid CD16 CD13, HLADr Defines acute promyelomonocytic leukemia CD71, CD3, CD4 Activation of T-helper/inducer cell subset CD20, CD79, CD22 Evaluation of CD79 to resolve certain B-cell malignancies CD33, UIC2, CD34 Evaluate drug resistance or progenitor cells Source: Roswell Park Cancer Institute
2) [4] is ordinarily expressed in certain differentiated cells of the mononuclear phagocyte system, notably osteoclasts and alveolar macrophages [1], and pathologically in Gaucher's cells [2] and in the hairy cells of leukemia reticuloendotheliosis [3].