HEYL

(redirected from hairy/enhancer-of-split related with YRPW motif 3)

HEYL

A gene on chromosome 1p34.3 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEYL is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It interacts with ARNT, GATA4, GATA6, HES1, HEY1, HEY2, HDAC1, NCOR1 and SIN3A
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