Laboratory experiments have shown that supporting cells from mice can be coaxed into becoming hair cells
in part by blocking production of p27.
It is known that the outer hair cells
in the basal turn of the cochlea are the cochlear components most susceptible to injury from ototoxic drugs such as aminoglycosides.
Combining this new knowledge about Lgr5-expressing cells with the previous finding that Notch inhibition can regenerate hair cells
will allow the scientists to design new hair cell
regeneration strategies to treat hearing loss and deafness.
The mechanisms that contribute to this marvelous transformation are beyond our presentation, but suffice it to say, different frequencies stimulate hair cell
hair bundles at different locations.
A person who loses their hearing due to a nerve loss, loses those hair cells
,'' he said.
In the inner ear, specialized sensors called auditory hair cells
are vital to the ability to hear.
Simultaneous exposure to ethyl benzene and noise: synergistic effects on outer hair cells
The tiny hair cells
in the inner ear can become damaged from the strong vibrations or from too much "wear and tear" on them.
Exposure to harmful sounds causes damage to the sensitive hair cells
of the inner ear and to the nerve of hearing.
biotech GenVec to develop gene-based treatments to replace hair cells
in the ear that transmit sound.
Summary: TEHRAN (FNA)- Researchers discovered that the hair cells
of the inner ear have a previously unknown "root" extension that may allow them to communicate with nerve cells and the brain to regulate sensitivity to sound vibrations and head position.
This leads to permanent damage to the outer hair cells
of the cochlea, resulting in permanent hearing loss.