Adjunct and alternative therapies included treatments to reduce poison absorption by topical application of creams, enhance toxin elimination by haemoperfusion or bioremediation and neutralise the poison by scavenging free organophosphate with cholinesterase-rich human plasma.
The seven studies on adjunct/alternate therapies in human poisoning included three studies on haemoperfusion (12-14), one systematic review on alkalinisation (15) and one study each on magnesium (16), plasma (9) and glycopyrrolate (17).
Haemoperfusion is effective for substances with a small [V.
Several animal experiments have evaluated the role of haemoperfusion in OP poisoning.
The impetus to use haemoperfusion in human OP poisoning came from studies in the 1970s that showed high clearance values of 83.
In a recent retrospective report, 25 patients with severe OP poisoning treated with haemoperfusion were compared with 27 patients with mild poisoning not receiving haemoperfusion (12).