haemolytic-uraemic syndrome


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haemolytic-uraemic syndrome (HUS)

The combination acute kidney insufficiency, haemolytic anaemia and a low platelet count (thrombocytopenia). Biopsy of kidney tissue shows a blood vessel disorder with thrombosis of the glomerular and other small vessels. In spite of the thrombocytopenia, blood clotting times are normal. The syndrome has many causes including Shiga toxin-producing E. coli infection in post-diarrhoea cases, other infections, pregnancy, drugs, cancers, systemic lupus erythematosus and organ transplants, but most probably relate ultimately to endothelial injury. Its effects may be very serious as almost any system of the body may be involved.
References in periodicals archive ?
The infection can cause the deadly complication - haemolytic-uraemic syndrome (HUS) - affecting the blood and kidneys.
Haemolytic-uraemic syndrome in childhood: surveillance and case-control studies in Italy.
She later developed the most severe form of EHEC infection, haemolytic-uraemic syndrome, in which the kidneys and nervous system fail and patients often suffer epileptic fits.