Lack of ADAMTS13 activity promotes von Willebrand factor induced platelet aggregation and microangiopathic haemolytic anaemia.
Haemolytic uraemic syndrome typically presents with acute renal failure, microangiopathic haemolytic anaemia and thrombocytopenia, is more common in children and is associated with a diarrhoeal illness in 80 to 90% of cases.
Both patients had classical features of thrombotic microangiopathy with microangiopathic haemolytic anaemia, thrombocytopenia and renal failure commencing in the first 48 hours after envenomation.
Severe, life-threatening intravascular haemolytic anaemia may occur.
Drug-induced haemolytic anaemia is typically a rare adverse drug reaction which is usually not identified before marketing of new drugs.
Shiga-toxin-producing Escherichia coli and haemolytic
The association of acute renal insufficiency, thrombocytopenia due to peripheral destruction of platelets, and haemolytic anaemia with the presence of schistocytes was suggestive of thrombotic microangiopathy and treatment with plasma exchange was instituted along with haemodialysis.
The diagnosis of thrombotic microangiopathy is based on a pentad of signs and symptoms: thrombocytopenia, microangiopathic haemolytic anaemia, neurologic abnormalities, renal failure and fever.
Haemolytic uraemic syndrome and Shiga toxin-producing Escherichia coli infection in children in France.
Diarrhoea in close contacts as a risk factor for childhood haemolytic uraemic syndrome: the CPKDRC co-investigators.