The lower levels of HbE compared to other P-chain structural variants could be attributed to HbE being a thalassaemic haemoglobinopathy with unstable m-RNA (16).
In addition, some cases (n= 4) showed isolated raised HbF, where no other abnormality related to haemoglobinopathy was found and family study was negative.
A remarkably useful book, Variant Haemoglobins will be valuable for haematopathologists, clinical and laboratory haematologists in practice and in training and all laboratory staff involved in haemoglobinopathy diagnosis.
Wild PhD FIBMS Clinical Scientist Haemoglobinopathy Genetics Centre University College Hospitals London NHS Foundation Trust London
Four fetuses were therefore considered at increased risk of a haemoglobinopathy
, while two were at reduced risk.
Pattern of musculoskeletal infection and haemoglobinopathy
less common causes include haemoglobinopathy
, major burns, pancreatitis, overwhelming infections, tumours, blood transfusions, liposuction and intraosseus infusions (3, 4).
BRIGHT GIFT: At the presentation are (from left, front) patient Noreen Saeed, nurse Emma Herbert, Sister Sab Kular, Nova Spencer, Sister Sindy Singh, rear, from left)) haemoglobinopathy
officer Manjit Bath, ward manager Lindsay Randle, parent Shamim Akhtar and information officer Gwyneth Roe.
1,2,4) Anaemia may develop in children already debilitated by other conditions such as nutritional deficiencies, bacteraemia, human immunodeficiency viral (HIV) infections, haemoglobinopathy
, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hookworm infestation and leukaemia.
Haemoglobin E disorder: A well-known haemoglobinopathy
, haemoglobin E is peak endemic in this area, in northeastern of Thailand and Laos (9,10).
Prince Edward, who previously visited the hospital to open the haemoglobinopathy
unit in 2005, was ushered into the new unit to meet patients and staff, including Amina Mahmood, of Yardley.
Evaluation of the Primus Corporation CLC330TM HPLC system for haemoglobinopathy