hemoglobin S

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he·mo·glo·bin S

an abnormal Hb with substitution of a valyl residue for a glutamyl residue at the sixth position of the β chain; the formula is α2Aβ2S, or, more specifically, α2Aβ26Glu→Val. Heterozygous state: sickle cell trait, no anemia, Hb S 20-45% of total, the rest Hb A. Homozygous state: sickle cell anemia, Hb S 75-100% of total, the rest Hb F or Hb A2.

hemoglobin S (Hb S)

hemoglobinopathy characterized by the substitution of the amino acid valine for glutamic acid at position 6 in the beta chain of the hemoglobin molecule. Hemoglobin S migrates to between hemoglobin C and hemoglobin A in hemoglobin electrophoresis. As the hemoglobin S become deoxygenated, red cells become sickle-shaped, occluding capillaries. If the proportion of Hb S to Hb A is large, as in sickle cell anemia, local infarction occurs. See also sickle cell anemia, sickle cell crisis, sickle cell trait.

he·mo·glo·bin S

(Hb S) (hē'mō-glō'bin)
An abnormal hemoglobin that renders erythrocytes subject to sickling and hemolysis at reduced oxygen tension; makes up 70-100% of hemoglobin in people with sickle cell anemia.
Synonym(s): sickle cell hemoglobin, haemoglobin S.

Hemoglobin S

Hemoglobin produced in association with the sickle cell trait; the beta-globin molecules of hemoglobin S are defective.
Mentioned in: Sickle Cell Disease

Patient discussion about hemoglobin S

Q. Can Jantoven cause hemoglobin to drop?

A. Yes. In that case, you may consider consulting a doctor, since it may result from bleeding that may necessitate treatment.

Q. What is the Definition of Anemia? My doctor told me I have anemia, based on my latest blood tests. What is anemia?

A. In laymans terms it is low iron. Most women get it sometime in their lives due to menstration and other factors. You need to increase your iron intake. Lots of beets, beans, spinich, and lots of other foods can help.

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