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a localized edematous reaction of the deep dermis or subcutaneous or submucosal tissues appearing as giant wheals; urticaria is the same physiologic reaction occurring in the superficial portions of the dermis.
hereditary angioedema an autosomal dominant disorder of the complement system manifested as recurrent episodes of edema of the skin, upper respiratory tract, and gastrointestinal tract. It may be mediated by such factors as minor trauma, sudden changes in environmental temperature, and sudden emotional stress. adj., adj angioede´matous.


Recurrent large circumscribed areas of subcutaneous or mucosal edema of sudden onset, usually disappearing within 24 hours; frequently, an allergic reaction to foods or drugs.


/an·gio·ede·ma/ (-ĕ-de´mah) a vascular reaction involving the deep dermis or subcutaneous or submucosal tissues, representing localized edema caused by dilatation and increased permeability of the capillaries, and characterized by the development of giant wheals.
hereditary angioedema  an autosomal dominant disorder of C1 inhibitor (C1 INH), which causes uncontrolled activation of the classical complement pathway, manifested as recurrent episodes of edema of the skin and upper respiratory and gastrointestinal tracts with increased levels of several vasoactive mediators of anaphylaxis. It may be mediated by such factors as minor trauma, sudden changes in environmental temperature, and sudden emotional stress.


Rapid swelling of the subcutaneous tissues and submucosal membranes, often accompanied by urticaria.


a dermal, subcutaneous, or submucosal swelling that is acute, painless, and of short duration. It may involve the face, neck, lips, larynx, hands, feet, genitalia, or viscera. Angioedema may be hereditary or the result of a food or drug allergy, an infection, emotional stress, or a reaction to blood products. Treatment depends on the cause. Severe angioedema may require subcutaneous injections of epINEPHrine, intubation, or tracheotomy to prevent respiratory obstruction. Prevention depends on the identification and avoidance of causative factors. Also called angioneurotic edema. See also anaphylaxis, serum sickness, urticaria.
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angioneurotic oedema

(1) Acquired angioedema, a chronic and potentially fatal condition characterised by abdominal pain and episodic localised subcutaneous, periorbital, periocular and laryngeal oedema, due to an absence of C1 esterase inhibitor.
Clinical findings
Recurrent oedema; abdominal pain; laryngeal oedema, which may compromise breathing.

History of recurrent angioedema, abnormally low or absent C1 esterase inhibitor in blood.
Allergies (e.g., foods, pollen, insect bites); drugs (e.g., ACE inhibitors, salicylates); stress; exposure to cold, water, sunlight or heat.

Epinephrine, antihistamines, corticosteroids (androgens).

(2) Hereditary angioneurotic oedema, see there


1. A general term for a vascular reaction of the deep dermis, subcutaneous or submucosal tissues, which corresponds to localized edema 2º to vasodilation and ↑ capillary permeability.
2. Angioneurotic edema, see there.


1. Recurrent large circumscribed areas of subcutaneous edema of sudden onset, usually disappearing within 24 hours; seen mainly in young women, frequently as an allergic reaction to foods or drugs.


An allergic skin disease characterized by patches of confined swelling involving the skin the layers beneath the skin, the mucous membranes, and sometimes the viscera—called also angioneurotic edema, giant urticaria, Quincke's disease, or Quincke's edema.


Henry M., U.S. physician, 1844-1920.
Bannister disease - recurrent large circumscribed areas of subcutaneous edema, frequently an allergic reaction to foods or drugs. Synonym(s): angioedema


Heinrich Irenaeus, German physician, 1842-1922.
Quincke capillary pulsation - Synonym(s): Quincke pulse
Quincke disease - Synonym(s): Quincke edema
Quincke edema - recurrent, large, circumscribed areas of subcutaneous edema of sudden onset, usually disappearing within 24 hours. Synonym(s): angioedema; Milton disease; Milton urticaria; Quincke disease; Quincke I syndrome
Quincke meningitis - intracranial hypertension of unknown origin.
Quincke needle
Quincke pulse - capillary pulsation, a sign of arteriolar dilation and especially well seen in severe aortic insufficiency. Synonym(s): Quincke capillary pulsation; Quincke sign
Quincke puncture - a puncture into the subarachnoid space of the lumbar region to obtain spinal fluid for diagnostic or therapeutic purposes. Synonym(s): lumbar puncture
Quincke sign - Synonym(s): Quincke pulse
Quincke spinal needle
Quincke I syndrome - Synonym(s): Quincke edema


recurrent, sudden-onset, non-inflammatory swelling of skin and mucous membranes, viscera and brain; characteristic of anaphylaxis


Recurrent large circumscribed areas of subcutaneous or mucosal edema of sudden onset, usually disappearing within 24 hours; often due to an allergic reaction to foods or drugs.
Synonym(s): angioneurotic edema.

angioedema (angioneurotic edema, Quincke's disease) (an´jēōədē´mə),

n the spontaneous swelling of the lips, cheeks, eyelids, tongue, soft palate, pharynx, and glottis, frequently associated with allergy to food or drugs and lasting from several hours to several days. Involvement of the glottis results in obstruction of the airway.
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a condition characterized by the sudden and temporary appearance of large areas of painless swelling in the subcutaneous tissue or submucosa, with or without pruritus. Caused by immunological reactions, usually immediate type hypersensitivities. Sometimes referred to as angioneurotic edema.

hereditary angioedema
in humans, the periodic occurrence of angioedema caused by a deficiency of the complement regulatory protein.

Patient discussion about angioedema

Q. Is severe diarrhea sign of angioedema? I have sudden onset of painful diarrhea with stomach pain.

A. Severe diarrhea can be a sign of angioedema but it is a very unlikely way of angioedema to show, especially if that is the only symptoms and there is no obvious seen swelling of skin or shortness of breath. Stomach ache with diarrhea is usually caused by an infection, most likely a viral infection, and should pass within a few days. If symptoms are unbarable or continue, you should see your doctor.

Q. What can cause an angioedema on 15 year old girl? I’ve been getting angioedema signs on my left arm for the past few weeks, not severe but it itches and sure don’t help my low-as-it-is self esteem…

A. The following may cause angioedema -

Animal dander
Certain medications (drug allergy)
Emotional stress
Exposure to water, sunlight, cold or heat
Foods (such as berries, shellfish, nuts, eggs, milk, other)
Insect bites

Hives or angioedema may also occur after an illness or infection.
Try to see if you were exposed to any of this and report it to your Dr.

More discussions about angioedema
References in periodicals archive ?
A diagnosis of HAE type II was established based on clinical and laboratory findings with sensitivity to estrogen hormone as symptoms were triggered and worsened by OCP intake, menstruation, and pregnancy.
According to the levels of C4 and C1-INH HAE can be classified into two different types traditionally.
The Company is currently developing products to expand its angioedema portfolio, including a suite of diagnostic assays to identify plasma kallikrein mediated (PKM) angioedema and a therapeutic candidate, DX-2930, for the prophylactic treatment of HAE and other PKM angioedemas.
2) HAE is passed on in an autosomal dominant fashion, and thus the offspring of affected individuals have a 50% chance of being affected.
Treatment of HAE can be prophylactic or directed to acute attacks.
The data provides validation of the positive effect of DX-88 in HAE patients.
Shire investigated the use of FIRAZYR in paediatric patients in an open-label, non-randomised, single-arm study involving 32 paediatric patients with HAE.
The previous episode saw Wang So interrogating Hae Su about the assassins who tried to kill Crown Prince Mu.
We look forward to them now extending the commercialisation of RUCONEST by providing HAE patients in South Korea with a new, safe and effective treatment to treat their HAE atttacks.
Under the clinical trial, a total of 20 children with HAE were treated for 73 HAE attacks at a dose of 50 IU/kg (up to a maximum of 4200 IU).
A publicly traded, Massachusetts-based biotechnology firm, Dyax is mainly focused on the development of plasma kallikrein (pKal) inhibitors for the treatment of HAE, a debilitating and sometimes life-threatening rare genetic disease.