PDE1C

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PDE1C

A gene on chromosome 7p14.3 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing cAMP and cGMP to AMP and GMP. As with other PDE1s, PDE1C is activated by calmodulin in the presence of Ca2+.