CARD9

(redirected from hCARD9)

CARD9

A gene on chromosome 9q34.3 that encodes a protein which activates NF-kappa-B by binding to BCL10 by a CARD–CARD interaction. It is highly expressed in the spleen, less so in the liver, placenta, lung, leukocytes and brain.

Molecular pathology
CARD9 mutations cause autosomal recessive chronic mucocutaneous candidiasis type 2.