ITGB7(redirected from gut-homing receptor beta subunit)
ITGB7A gene on chromosome 12q13.13 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-7 chain partners with the alpha-4 chain—Peyer patches-specific homing receptor LPAM-1—and serves as an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue. The A4/B7 heterodimer interacts with the cell surface adhesion molecules MADCAM1, VCAM1 and fibronectin.
A4B7 binds to HIV-1’s gp120 at the tripeptide LDI, facilitating HIV-1 entry to gut-associated lymphoid tissue, which is regarded as a major trigger of AIDS disease.