guanylyl cyclase


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guan·y·late cy·clase

(gwahn'i-lāt sī'klās),
An enzyme analogous to adenylate (adenylyl) cyclase, but cyclizing guanosine 5'-triphosphate to guanosine 3':5'-cyclic monophosphate and also producing pyrophosphate; activated by nitric oxide.

guanylyl cyclase

An enzyme that catalyses the transformation of GTP to GMP.
References in periodicals archive ?
Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer.
Role of guanylyl cyclase activation via thiamine in suppressing chemically-induced writhing in mouse.
Pre-incubation with L-NAME (unspecific nitric oxide synthase inhibitor), indomethacin (unspecific COX inhibitor), ODQ (soluble guanylyl cyclase inhibitor), atropine (cholinergic receptor antagonist), TEA (unspecific potassium channel blocker) reduced relaxations induced by 1.
3] Nonstandard abbreviations: BNP, B-type natriuretic peptide; GC-A, guanylyl cyclase receptor-A; cGMP, cyclic guanosine monophosphate; aa, amino acid; proBNP, pro-B-type natriuretic peptide; HF, heart failure; NT-proBNP, aminoterminal proBNP; NHS, nonimmune horse serum; LV, left ventricle; PVDF, polyvinylidene difluoride; ANP, atrial natriuretic peptide; His-tag, Histidinetagged; PC-1, prohormone convertase-1; DPP, dipeptidyl-peptidase.
The research will seek to further understand the potential of a novel, engineered guanylyl cyclase (GC) activator, cenderitide, to reduce the level of cardiac and renal injury following a myocardial infarction, or heart attack.
Millennium's oncology pipeline also includes an anti-PSMA antibody currently in phase I clinical trials for advanced prostate cancer, and guanylyl cyclase C (GC-C), a protein uniquely expressed on the cell surface of colorectal tumors, and its related ST ligand.
The company says that GCC-B1 can find one cancer cell in 10,000,000 normal cells by detecting the presence of guanylyl cyclase C (GC-C), which is found on metastatic colorectal cancer cells.
GCC-B1(TM) can find 1 cancer cell in 10,000,000 normal cells by detecting the presence of guanylyl cyclase C (GC-C), which is found on metastatic colorectal cancer cells.
The Company's newly established sales force will be on hand to introduce Previstage(TM) GCC, the first molecular diagnostic test for the staging of colorectal cancer and educate clinicians on the science of guanylyl cyclase C (GCC).
Previstage GCC identifies the expression of the guanylyl cyclase C (GCC) gene, a biomarker that is normally found exclusively in the intestine.