Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl
Bisphenol-A inhibits duodenal movement ex vivo of rat through nitric oxide-mediated soluble guanylyl
cyclase and a-adrenergic signaling pathways.
Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl
cyclase and the cGMP-dependent protein kinase.
7] M ODQ, an inhibitor of nitric oxide-sensitive guanylyl
cyclase; iv) [10.
Additionally, we recovered transcripts homologous to the G-protein beta subunit, the G-protein gamma subunit (gngt1), protein kinase C (PKC), cyclic nucleotide gated-channel alpha 1 (cnga1), regulator of G-protein-signaling 9 (RGS9), retinal degeneration B (rdgB), arrestin (arr), guanylyl
cyclase (GC), and cyclic nucleotide phosphodiesterase (PDE6abc)--all of which are implicated with phototransduction in ciliary-type photoreceptor cell systems (Fain et al.
Hydroxyurea induses fetal haemoglobin by the nitric oxide dependent activation of soluble guanylyl
Binding of these guanylyl
cyclase-coupled receptors leads to an increase in cGMP, which has downstream effects of diuresis and natriuresis, vasodilation, inhibition of the renin-angiotensin-aldosterone system, enhanced myocardial relaxation, inhibition of fibrosis and hypertrophy, promotion of cell survival, and inhibition of the inflammatory response.
3,4,6] Endothelial NO synthesised from l-arginine activates soluble guanylyl
cyclase (sGC), converting cyclic guanosine triphosphate (cGTP) to cyclic guanosine monophosphate (cGMP), which facilitates smooth muscle relaxation.
Once NO has been produced, it goes into the cells and stimulates the synthesis of cyclic guanosyn mono-phosphate (cGMP) by enzyme guanylyl
Third, we hypothesized that high CGA altered the response of vascular smooth muscle to NO via an inhibitory effect on the soluble guanylyl
cyclase (sGC) signaling pathway.
Toxins are then released to activate the production of the enzymes adenylate cyclase and guanylyl
cyclase, which increases the intracellular concentration of cyclic adenosine monophosphate (cAMP), generating a greater transfer of sodium bicarbonate and water from the gut lumen cells (MORES & MORENO, 2007).
The nitric oxide produced by endothelium rapidly diffuses into the smooth muscle cell where it activates a soluble guanylyl
cyclase (sGC), which generates cyclic guanosine monophosphate (cGMP) that mediates vasodilation (Mondaca et al.