guanylate cyclase


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guan·y·late cy·clase

(gwahn'i-lāt sī'klās),
An enzyme analogous to adenylate (adenylyl) cyclase, but cyclizing guanosine 5'-triphosphate to guanosine 3':5'-cyclic monophosphate and also producing pyrophosphate; activated by nitric oxide.

guanylate cyclase

enzyme catalyzing the synthesis of 3′5′ cyclic-GMP from GTP in photoreceptor cells of the retina in its dark state. cGMP binds to Na+-channels of the retinal cells, causing them to open.
References in periodicals archive ?
In chapter four, the global PAH market has been segmented into prostacyclin and prostacyclin analogs, endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, and soluble guanylate cyclase (sGC) stimulators, based on the commercially-available drug classes, to treat PAH.
based company MSD (through a subsidiary) in the field of soluble guanylate cyclase (sGC) modulation.
The aim of this study was to determine if Arg supplementation to control (C), overfed (O), and underfed (U) ewes impacts 1) body weight (BW) and body condition score (BCS), 2) P4 serum concentration and content in the CL, 3) CD31 (an endothelial cell marker), Ki67 (a proliferating cell marker), endothelial nitric oxide synthase (eNOS), and NO receptor soluble guanylate cyclase (sGC) protein and/or mRNA expression in the CL, and 4) mRNA expression of selected angiogenic factors in CL during the estrous cycle.
NO interacts with the heme group in the enzyme guanylate cyclase in the presence of cGMP [6].
The non-selective nitric oxide synthase inhibitor L-NAME, as well as the soluble guanylate cyclase inhibitor MB, attenuated the relaxation of EOFAZ in endothelium-intact rat thoracic aortic rings.
2+] in smooth muscle cells, due not only to the activation of soluble guanylate cyclase (Arnold et al.
It binds to guanylate cyclase C locally in the intestine, with no measurable blood plasma concentrations, resulting in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).
After differentiation: receptor guanylate cyclase, nitric oxide receptor, G-protein-coupled receptor, integrin, cadherin, gap junction, ligand-gated cation channel.
It may be the first clear example of a membrane-associated receptor that activates guanylate cyclase directly," he says.
The soluble guanylate cyclase (sGC) enzyme, which is important for the function of both the blood vessels and the heart, is insufficiently stimulated in heart failure due to impaired NO (nitric oxide) availability and endothelial dysfunction.
The development and commercialization of riociguat is part of the worldwide strategic collaboration with MSD (through a subsidiary) in the field of soluble guanylate cyclase (sGC) modulation.
Our results showed there were significantly inhibited the vasodilator effect caused by EOFAZ on the isolated rat aortic rings both preincubated with L-NAME, an inhibitor of NOS activity, and preincubated with MB, an inhibitor of guanylate cyclase activity.

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