guanylate cyclase


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guan·y·late cy·clase

(gwahn'i-lāt sī'klās),
An enzyme analogous to adenylate (adenylyl) cyclase, but cyclizing guanosine 5'-triphosphate to guanosine 3':5'-cyclic monophosphate and also producing pyrophosphate; activated by nitric oxide.

guanylate cyclase

enzyme catalyzing the synthesis of 3′5′ cyclic-GMP from GTP in photoreceptor cells of the retina in its dark state. cGMP binds to Na+-channels of the retinal cells, causing them to open.
References in periodicals archive ?
5), who reported that its role is achieved by activating platelet soluble guanylate cyclase and upregulation of adenosine monophosphate and cyclic guanosine monophosphate.
NASDAQ: IRWD) has initiated STRONG-SCD, a multicenter, randomized, double-blind, placebo-controlled, dose-ranging Phase II clinical trial designed to assess the safety and tolerability of oral, once-daily IW-1701, an orally administered soluble guanylate cyclase (sGC) stimulator,in patients with sickle cell disease, the company said.
He led the development of Trulance from inception to FDA approval, having co-invented and pioneered Synergy's platform technology surrounding the therapeutic applications of guanylate cyclase C agonists for functional GI disorders, inflammatory bowel disease, GI cancer, cholesterol lowering, asthma and other lung diseases.
We have previously shown that the nitric oxide donor S-nitroso-n-acetylpenicillamine (SNAP) and the particulate guanylate cyclase activator B-type natriuretic peptide (BNP) exert a cytoprotective effect against simulated ischemia/reperfusion (SI/R) injury in primary neonatal rat cardiomyocytes [14].
The aim of this study was to determine if Arg supplementation to control (C), overfed (O), and underfed (U) ewes impacts 1) body weight (BW) and body condition score (BCS), 2) P4 serum concentration and content in the CL, 3) CD31 (an endothelial cell marker), Ki67 (a proliferating cell marker), endothelial nitric oxide synthase (eNOS), and NO receptor soluble guanylate cyclase (sGC) protein and/or mRNA expression in the CL, and 4) mRNA expression of selected angiogenic factors in CL during the estrous cycle.
Shannon Boye, assistant professor of ophthalmology at the U of Florida, to fund her LCA-1 research focused on the gene mutation called guanylate cyclase (GUCY2D).
NO interacts with the heme group in the enzyme guanylate cyclase in the presence of cGMP [6].
Uroguanylin (UGN) is an endogenous peptide that acts on membrane-bound guanylate cyclase receptors of intestinal and renal cells increasing cGMP production and regulating electrolyte and water epithelial transport.
The non-selective nitric oxide synthase inhibitor L-NAME, as well as the soluble guanylate cyclase inhibitor MB, attenuated the relaxation of EOFAZ in endothelium-intact rat thoracic aortic rings.
Biotin (vitamin B7) which was introduced as a gene regulator, can increase insulin secretion by affecting beta cells of pancreatic islets, as well as enhance glycolysis pathway, and improves insulin function in muscles by provoking guanylate cyclase activity.
ATLANTA--Riociguat, a novel first-in-class guanylate cyclase stimulator, significantly improved 6-minute walk distance in patients with inoperable chronic thromboembolic pulmonary hypertension as well as in patients with symptomatic pulmonary arterial hypertension.
Roberts, both of the Laboratory of Pathology in NIH's National Cancer Institute (NCI), found in mouse and human cell experiments that amyloid-beta, the main component of the plaques that accumulate on brain cells in Alzheimer's, binds to a cell surface receptor called CD36, which causes decreased activity of the enzyme soluble guanylate cyclase to reduce NO signaling.

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