All muscarinic receptors are coupled to guanyl
proteins that determine the specificity of their actions.
Therefore, to further study the involvement of NO in the relaxant effect of PA we examined, more distally in the NOS-sGC signaling pathway, the effects of a non-selective soluble guanyl
cyclase inhibitor methylene blue and of a selective blocker of ATP-sensitive [K.
It is believed that the non guanyl
cyclase linked receptor, natriuretic peptide receptor type C (NPR-C), functions as a clearance receptor by binding and internalizing natriuretic peptides (21).
Binding of the NPs to NPR-A and -B stimulates intrinsic guanyl
cyclase activity and the production of the intracellular messenger, cGMP.
Role of fluidity of membranes on the guanyl
nucleotide-dependent binding of cholecystokinin 8-S to rat brain cortical membranes.
That protein is termed a "G-protein" because of the fact that its enzymatic activity is determined by its binding to a guanyl
nucleotide: it is active when bound to GTP (guanosine triphosphate) from the cytoplasm but inactive when bound to GDP.
T cells contain two types of Ras activators: a molecule called SOS and another called Ras guanyl
nucleotidereleasing protein, or RasGRP.