guanosine monophosphate


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to guanosine monophosphate: adenosine monophosphate, cyclic guanosine monophosphate, Inosine monophosphate

guanosine

 [gwah´no-sēn]
a nucleoside, guanine riboside, one of the major constituents of RNA.
cyclic guanosine monophosphate a cyclic nucleotide, guanosine 3′,5′-cyclic monophosphate, an intracellular “second messenger” similar in action to cyclic adenosine monophosphate; the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function. Abbreviated 3′,5′-GMP, cGMP, and cyclic GMP.
guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.
guanosine triphosphate (GTP) a nucleotide required for RNA synthesis and involved in energy metabolism.

guanosine monophosphate

(mŏn′ō-fŏs′fāt′)
n.
GMP.

guanosine monophosphate (GMP)

a nucleotide that plays an important role in various metabolic reactions and in the formation of RNA from DNA templates.

guanosine

a nucleoside, guanine riboside, one of the major constituents of nucleic acids.

cyclic guanosine monophosphate (cyclic GMP, cGMP)
a cyclic 3′,5′-phosphate that acts as an intercellular second messenger mediating the activity of hormones and other substances; essential in vision where cGMP concentrations increase in the dark.
guanosine monophosphate
a nucleotide important in metabolism and nucleic acid synthesis; called also GMP.
guanosine pentophosphate
involved with guanosinetetraphosphate in the so called stringent response of bacteria in which, because the cell does not have a sufficient pool of amino acids to maintain protein synthesis, tRNA and rRNA synthesis is reduced by about 20-fold, which suspends many of the cells' activities until conditions improve.
guanosine tetraphosphate
see guanosine pentophosphate (above).
guanosine triphosphate
an energy-rich compound involved in several metabolic reactions; called also GTP.
References in periodicals archive ?
This suggests that MPNs were preferentially methylated by thiopurine methyltransferase between 6 and 20 h, rather than converted by inosine monophosphate dehydrogenase and guanosine monophosphate synthetase into TGNs.
For studying the possible participation of the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant like effect of essential oil in FST, mice were pretreated with L-arginine, a precursor of nitric oxide (750 mg/kg, i.
The market is dominated by three major cyclic Guanosine Monophosphate (cGMP)-specific Phosphodiesterase type 5 (PDE5 inhibitors) including Viagra (sildenafil citrate), Cialis (tadalafil) and Levitra (vardenafil HCl).
IDX184 is a novel, liver-targeted nucleotide prodrug of 2'-methyl guanosine monophosphate, which includes Idenix's proprietary liver-targeting technology.
Nasdaq: IDIX), a biopharmaceutical company engaged in the discovery and development of drugs for the treatment of human viral diseases, today announced interim data from a 14-day, phase IIa clinical trial evaluating IDX184, a novel liver-targeted nucleotide prodrug of 2'-methyl guanosine monophosphate, in HCV-infected patients.
Increases in plasma concentrations of cyclic guanosine monophosphate (cGMP) levels, a pharmacological response consistent with the effects of endogenous natriuretic peptides on cardiovascular function, similar to results seen in an earlier Phase 1 study.
The evaluations included safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide.
The evaluations will include safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including endogenous messenger levels such as cyclic guanosine monophosphate.
In addition to identifying any trends in the concomitant use of alpha- blockers with the introduction of selective inhibitors of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), this analysis also examined the side effect profile of the two alpha-blockers when used to treat BPH without concomitant use of the erectile dysfunction drug.
Sildenafil, in the form of a citrate salt, is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase Type 5 (PDE5).
PDE inhibitors maintain levels of a chemical called cyclic guanosine monophosphate (cGMP) that precipitates smooth muscle relaxation, leading to an erectile response.