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guanosine |
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guanosine /gua·no·sine/ (gwah´no-sen) a purine nucleoside, guanine linked to ribose; it is a component of RNA and its nucleotides are important in metabolism. Symbol G. cyclic guanosine monophosphate 3',5'-GMP, cGMP, cyclic GMP; a cyclic nucleotide that acts as a second messenger similar in action to cyclic adenosine monophosphate but generally producing opposite effects on cell function. guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis. guanosine triphosphate (GTP) an energy-rich compound involved in several metabolic reactions and an activated precursor in the synthesis of RNA.
guanosine (gwän´ n a compound derived from a nucleic acid, composed of guanine and a sugar, D-ribose. Guanosine is a major molecular component of the nucleotides guanosine monophosphate and guanosine triphosphate and of DNA and RNA. guanosine triphosphate (GTP), n a high-energy nucleotide, similar to adenosine triphosphate, that functions in various metabolic reactions such as the activation of fatty acids and the formation of the peptide bond in protein synthesis. guanosine a nucleoside, guanine riboside, one of the major constituents of nucleic acids. cyclic guanosine monophosphate (cyclic GMP, cGMP) a cyclic 3',5'-phosphate that acts as an intercellular second messenger mediating the activity of hormones and other substances; essential in vision where cGMP concentrations increase in the dark. guanosine monophosphate a nucleotide important in metabolism and nucleic acid synthesis; called also GMP. guanosine pentophosphate involved with guanosinetetraphosphate in the so called stringent response of bacteria in which, because the cell does not have a sufficient pool of amino acids to maintain protein synthesis, tRNA and rRNA synthesis is reduced by about 20-fold, which suspends many of the cells' activities until conditions improve. guanosine tetraphosphate see guanosine pentophosphate (above). guanosine triphosphate an energy-rich compound involved in several metabolic reactions; called also GTP. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The mutation leads to a loss of guanosine triphosphatase activity and thus to adenyl cyclase overactivity and subsequent overproduction of cyclic adenosine monophosphate (cAMP). 8-OHdG is formed in a promutagenic DNA lesion induced by the reaction of hydroxyl radicals with guanosine at the C8 site in DNA (Kasai et al. This same biosynthetic pathway (mevalonate production) leads to the prenylation, or activation, of regulatory proteins such as guanosine triphosphate (GTP)-binding proteins. |
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