G proteins

(redirected from guanine nucleotide-binding protein)

G pro·teins

intracellular membrane-associated proteins activated by several (for example, β-adrenergic) receptors; they serve as second messengers or transducers of the receptor-initiated response to intracellular elements such as enzymes to initiate an effect. These proteins have a high affinity for guanine nucleotides and hence are named G proteins.

G proteins

Cell messengers that relay signals from over 1000 different cell membrane receptors to many different intracellular effectors such as enzymes and ion channels. G proteins have three subunits, alpha, beta, and gamma, each coded for by a different gene, selected from a total of 34 genes. G protein function is switched on and off by the binding and hydrolysis of guanosine triphosphate to the alpha subunit which is loosely attached to the others. Binding causes the beta and gamma fragments to separate as a dimer and to activate downstream effectors.
References in periodicals archive ?
Guanine nucleotide-binding protein subunit alpha-s (Gn[alpha]s) is closely related to the alpha subunits of the s class.
2008) and Blocks (Henikoff & Henikoff, 1994) databases was done with the following G domain primary structures as queries: (c-Ha-ras1 (HRas precursor, P01112), Guanine nucleotide-binding protein [G.
2 [Z72518] 7 AA269177 guanine nucleotide-binding protein G(O), 5 alpha subunit [P30033] A1216928 ORF N118 [D84656] 20 AA269293 Xenlia DG42 protein [P13563] 7 AA269295 ran=25 kda ras-related protein [239838] 7 AA269296 POLIM genome polyprotein [P03299] 5 AA269297 f549 [AE000312] 12 AA269298 RNA-directed RNA polymerase (ORF 1A) 8 [P19751] AA269299 AT-motif binding factor [D26046] 7 AA525639 thioredoxin [P34723] 23 AA525641 dTDP-glucose 4-6-dehydratase [D90911] 35 AA525642 hypothetical protein ZC84.
Measurement of guanine nucleotide-binding protein activation by [A.
Differential susceptibility of guanine nucleotide-binding proteins to pertussis toxin-catalyzed ADP-ribosylation in brain membranes of two congeneric marine fishes.
The largest family of cell-surface receptors are called G-protein-coupled receptors (GPCRs) (Figure 2) because they are associated with guanine nucleotide-binding proteins (G proteins).
In APC, volatile anaesthetics appear to mediate their protection in cardiomyocytes by selectively priming sarcolemmal and mitochondrial adenosine-triphosphate-sensitive potassium channels through triggering a complex signal cascade involving protein kinase C, protein tyrosine kinase, second messenger signal systems such as guanine nucleotide-binding proteins and by the influence on [Ca.
Guanine nucleotide-binding proteins (G proteins) are the important second messengers among various signalling pathways.
activities, such as the citric acid cycle and the activation of guanine nucleotide-binding proteins (G-proteins), which typically switch between
GPCRs transmit extracellular signals by binding coupled guanine nucleotide-binding proteins, or G proteins, in the cytoplasm.
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