VAV3

(redirected from guanine nucleotide exchange factor VAV3)

VAV3

A gene on chromosome 1p13.3 that encodes a member of the VAV guanine nucleotide exchange factor (GEF) family of genes. VAV3 is GEF for the Rho family of Ras-related GTPases, and plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Mentioned in ?
Full browser ?