It is well known that the transfer of the amidino group of arginine to glycine to yield L-ornithine and guanidinoacetate
(GM), which is catalyzed by L-arginine:glycine amidinotransferase, represents the first of two steps in the biosynthesis of Cr.
methyltransferase activity in growing male rats fed on a raw field bean (Vicia faba L.
It is noteworthy that the formation of creatinine from methylation of guanidinoacetate
accounts for approximately 75% of all folate-dependent transmethylation reactions (Barr et al.
In a second reaction, catalyzed by guanidinoacetate
is methylated by S-adenosylmethionine to form S-adenosylhomocysteine and creatine (BLOCH; SCHOENHEIMER, 1941; BORSOOK; DUBNOFF, 1945).
Spencer has a guanidinoacetate
methyltransferase deficiency, which means his muscles do not work properly and he needs to be fed through a tube.
and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate
The formation of creatine from methylation of guanidinoacetate
has been estimated to account for approximately 75% of transmethylation reactions (Mudd and Poole 1975).
The methyl group can be donated to a variety of macromolecules, such as DNA, RNA, proteins, and lipids, as well as to (small) precursor molecules such as guanidinoacetate
Although this association had not been previously reported, it is not surprising considering that the formation of creatine from methylation of guanidinoacetate
accounts for approximately 75% of all folate-dependent transmethylation reactions (Mudd and Poole 1975) and that creatine is the direct precursor of creatinine.
Biochemical detection of CDS relies on the determination of two main metabolites in biological fluids: guanidinoacetate
(GAA) and creatine.
1) and guanidinoacetate
N-methyltransferase (GAMT; EC 2.
For example, we detected a reduction in the expression of L-arginine-glycine amidinotransferase and guanidinoacetate
methyltransferase at days 1 and 6, respectively, after treatment with 5 mg/kg cisplatin, a dose that induced renal lesions.