growth hormone deficiency


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growth hormone deficiency

Hypopituitarism Endocrinology A condition which affects 1:4000 children; ♂:♀, 3-4:1 Etiology 70% of GHD is idiopathic and attributed to a prenatal insult, possibly due to hypothalamic dysfunction, given that GHD children secrete hGH after stimulation with GH-releasing hormone; GHD is associated with midline CNS and facial defects–eg, cleft lip and cleft palate; hypopituitarism may be linked to hypotelorism or a single giant upper central incisor; other causes include septooptic dysplasia, craniopharyngioma, intrasellar or suprasellar tumor Clinical Infants with intrauterine hypopituitarism may present at birth with hypoglycemic seizures, prolonged jaundice, and, if ♂, micropenis and undescended testes; linear growth rates as slow as 3 cm/yr; 10% with early onset disease have hypoglycemic seizures; 20% have chemical hypoglycemia; GHD children are proportional for age, have a prominant calvarium, and are often overweight for height, with prominant subcutaneous deposits of abdominal fat; they may have delayed puberty; electrolyte imbalances, diabetes insipidus, hypothyroidism are rare in Pts with idiopathic hypopituitarism; skeletal maturation is usually delayed; most have heights for bone age < third percentile Screening Assessment of bone age, x-rays of sella turcica, measure somatomedin C which, if normal virtually excludes GHD; pituitary function testing–provocative tests: maximal GH <7 ng/ml indicates impaired GH secretion; > 10 ng/ml excludes GHD Management GH replacement typically ↑ growth rate to 8-10 cm in first yr of therapy; treatment failure mandates workup for hypothyroidism or GH antibodies. See Septooptic dysplasia.

Patient discussion about growth hormone deficiency

Q. does the growth hormone have side effects and what are they?

A. Yes, it does, and not a few. They include, among others, pain in the joints, carpal tunnel syndrome, diabetes, pain at the injection site, problems with the thyroid gland, ear problems and many others. You may read more about side effects of growth hormone treatment (called Mecasermin or Somatropin) here: http://www.drugs.com/ppa/mecasermin.html

More discussions about growth hormone deficiency
References in periodicals archive ?
School authorities asked Rajat's parents to enrol him in a special school as he was suffering from growth hormone deficiency
From a pathology viewpoint, adult human growth hormone deficiency develops from abnormal functioning of the hypothalamus or pituitary gland.
Growth hormone deficiency in man: an isolated, recessively inherited defect.
Recombinant human growth hormone (rhGH) products are currently approved to treat multiple growth disorders, including pediatric and adult growth hormone deficiency, Turner Syndrome, chronic renal insufficiency, idiopathic short stature, Prader-Willi Syndrome, short children born small for gestational age, short bowel syndrome and muscle wasting in patients with HIV.
The guidelines are based on 166 published studies examining the prevalence and diagnosis of growth hormone deficiency in adults, as well as treatment strategies and their long-term risks and benefits, said Dr.
The small study included 55 patients with adult-onset growth hormone deficiency.
Victoria Bradley, above, who celebrates her eighth birthday today, has growth hormone deficiency and has to inject herself daily with a replacement synthetic drug.
The current synthetic formulation of hGH, manufactured by pharmAaceutical giants like Eli Lilly and Genentech, was approved by the Food and Drug Administration for adult use 10 months ago, but only for select patients who suffer from AIDS-related wasting syndrome; from a rare form of growth hormone deficiency, or for recovery from surgery on the pituitary gland (the body's source of growth hormone).
However, aside from those patients with classic growth hormone deficiency, there is uncertainty about what levels of GH would actually constitute a disease.
Exceedingly short children who fail to meet the technical definition of growth hormone deficiency still can benefit from treatment with a synthetic form of the hormone, according to a long-term study conducted at 10 major universities.
This report provides information on the therapeutic development for Growth Hormone Deficiency, complete with latest updates, and special features on late-stage and discontinued projects.
Another newly published market research report titled onEpiCast Report: Growth Hormone Deficiency - Epidemiology Forecast to 2024 provides an overview of the risk factors and global trends of GHD in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan).

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