The treatment included growth attenuation
via estrogen therapy, hysterectomy, and bilateral breast bud removal.
To the Editor: In the November-December 2010 issue, the Seattle Growth Attenuation and Ethics Working Group ("Navigating Growth Attenuation in Children with Profound Disabilities") analyzed the arguments for and against growth attenuation in children with permanent, profound intellectual disabilities and identified conditions under which its use may be ethically acceptable.
The group focused on growth attenuation rather than on the broader "Ashley Treatment," which also included a hysterectomy and breast bud removal.
Growth attenuation treatment for children such as Ashley challenges us to think beyond our initial reactions.
Growth attenuation through high dose estrogen therapy hastens the normal impact of puberty on girls' height.
As is common with protein therapeutics, antibodies to the protein complex were detected in most patients, but were not associated with growth attenuation
or adverse effects.
To the Editor: As the lawyer representing the hospital involved in the Ashley case, I write to offer my profound thanks to the Seattle Growth Attenuation and Ethics Working Group for their thorough, thoughtful, balanced, and considerate analysis in "Navigating Growth Attenuation in Children with Profound Disabilities" (Nov-Dec 2010).
We recognized that as a hospital that stood to benefit financially from approval of growth attenuation treatment, we had an irreducible conflict of interest that made it improper for the hospital to seek court approval for the care.
I was invited to join the Seattle Growth Attenuation
and Ethics Working Group--collective author of the lead article in this issue of the Report--but I begged off, claiming I had too many other things on my plate.
1) The article also offered an ethical justification for growth attenuation
, as this kind of intervention is known: it would let her parents lift and move her more easily, which the parents believed would allow her to participate in more social and recreational activities and would help them with routine activities like dressing and changing her diapers.
This bundle of interventions was described in detail at the University of Washington's May 16, 2007, Growth Attenuation
stimulates worries within the context of these social policies and attitudes.