group sequential design

group sequential design

A clinical trial design rgat allows one to examine the data at specific time points or after a defined number of patients have been entered and followed up, based on a stopping rule derived from repeated significance tests.
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The software uses monitoring and data analysis within a group sequential design to determine whether or not a study should continue.
It covers statistical methods for various adaptive designs such as adaptive group sequential design, adaptive dose-escalation design, adaptive seamless phase II/III trial design, and biomarker-adaptive design.
Mehta will present: "Confidence Intervals Following an Adaptive Group Sequential Design," and lead a technology workshop on "East 4: Adaptive and Group Sequential Design, Interim Monitoring, & Simulation.
It covers different types of designs, from group sequential design to early-phase oncology trials, as well as adaptive trial monitoring and advanced features of the software such as data generation and toolkits.
The Phase II trial evaluated the neuroprotective capacity of two combinations, AL-08 and minocycline versus AL-08 with celecoxib, using group sequential design and a natural history control group for a futility analysis.
S+SeqTrial uses monitoring and data analysis within a group sequential design to determine whether or not a study should continue.
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