griseofulvin


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gris·e·o·ful·vin

(gris'ē-ō-fŭl'vin),
A fungistatic antibiotic produced by Penicillium griseofulvin, P. patulum, and P. janczewskii; used in the systemic treatment of superficial fungal infections caused by the dermatophytes Microsporum, Trichophyton, and Epidermophyton; inhibits microtubule assembly.

griseofulvin

/gris·eo·ful·vin/ (gris″e-o-ful´vin) an antibiotic produced by Penicillium griseofulvum ; used as an antifungal in dermatophytoses.

griseofulvin

(grĭz′ē-ə-fŭl′vĭn)
n.
An antibiotic, C17H17ClO6, administered orally for the treatment of ringworm and other fungal infections of the skin, hair, and nails.

griseofulvin

[gris′ē·ōful′vin]
an antifungal.
indications It is prescribed in the treatment of certain fungal infections of the skin, hair, and nails.
contraindications Liver dysfunction, porphyria, or known hypersensitivity to this drug prohibits its use.
adverse effects The most serious adverse effects are blood dyscrasias. Headache, GI symptoms, and rashes also may occur.

griseofulvin

Microbiology An oral antifungal with an affinity for skin, used to treat dermatophytoses–eg, Epidermophyton spp, Microsporum spp, Trichophyton spp Adverse effects Headache, N&V, diarrhea, photosensitivity, fever, rash, dysfunction of hepatic, CNS, hematopoietic systems; it is teratogenic and carcinogenic in rodents. Cf Amphotericin B.

gris·e·o·ful·vin

(gris'ē-ō-ful'vin)
A fungistatic agent used in the systemic treatment of superficial fungal infections caused by certain dermatophytes, which inhibits microtubule assembly.

griseofulvin

An antifungal drug derived from a Penicillium mould that concentrates in the outer layers of the skin and in the nails and is thus useful in the treatment of ‘ringworm’ (TINEA) infections. Skin infections settle quickly, but tinea of the nails requires treatment for months. Brand names are Fulcin and grisovin.

griseofulvin

systemic antifungal agent used to treat widespread or intractable skin dermatophyte infections and onychomycosis; contraindicated in patients with severe liver disease, systemic lupus erythematosus, porphyria, pregnant and lactating women and infants; use has been largely superseded by newer antifungal agents, e.g. terbinafine; griseofulvin spray (400 μg puffs to a maximum of 1.2 mg/day) is an effective topical treatment for tinea pedis

gris·e·o·ful·vin

(gris'ē-ō-ful'vin)
A fungistatic antibiotic produced by Penicillium species; used in systemic treatment of superficial fungal infections.

griseofulvin

a fungistatic antibiotic produced by Penicillium griseofulvum used orally for treatment of fungal infections of the skin. Toxic effects include bone marrow suppression and teratogenicity.
References in periodicals archive ?
With regard to treatment, we found that itraconazole and terbinafine were more effective than griseofulvin in the management of adult TC.
The most common side effects associated with griseofulvin are headaches and gastrointestinal complaints.
Acomparison of itraconazole and griseofulvin in treatment of tinea corporis and tinea cruris: a double-blind study.
Griseofulvin Oral Suspension, USP acts systemically to inhibit the growth of Trichophyton, Microsporum, and Epidermophyton genera of fungi.
In larger studies of adults, pulse itraconazole cure rates are similar to courses of terbinafine and both are superior to griseofulvin.
They reported resistance to Fluconazole and Griseofulvin.
Oral antifungal agents, such as griseofulvin, itraconazole, terbinafine, and fluconazole, are effective.
Griseofulvin is derived from the penicillium species and is effective against all dermatophytes.
Eosinophilic cellulitis - A case study and management with griseofulvin.
Chemical compound supplier ACETO Corporation (NasdaqGS:ACET) revealed on Monday that it will introduce the first generic version of the 125mg and 250mg strengths of Ultramicrosize Griseofulvin Tablets USP in the market.
Six known compounds, cytochalasin J, dechlorogriseofulvin, demethylharzianic-acid, griseofulvin, harzianic acid and 2-hexylidene-3-methyl-succinic acid were identified from a rapid dereplication technique for fungal metabolites using an in-house UV library.
A meta-analysis of seven randomized controlled trials comparing griseofulvin and terbinafine in the treatment of tinea capitis resulted in a draw.