griseofulvin


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gris·e·o·ful·vin

(gris'ē-ō-fŭl'vin),
A fungistatic antibiotic produced by Penicillium griseofulvin, P. patulum, and P. janczewskii; used in the systemic treatment of superficial fungal infections caused by the dermatophytes Microsporum, Trichophyton, and Epidermophyton; inhibits microtubule assembly.

griseofulvin

/gris·eo·ful·vin/ (gris″e-o-ful´vin) an antibiotic produced by Penicillium griseofulvum ; used as an antifungal in dermatophytoses.

griseofulvin

(grĭz′ē-ə-fŭl′vĭn)
n.
An antibiotic, C17H17ClO6, administered orally for the treatment of ringworm and other fungal infections of the skin, hair, and nails.

griseofulvin

[gris′ē·ōful′vin]
an antifungal.
indications It is prescribed in the treatment of certain fungal infections of the skin, hair, and nails.
contraindications Liver dysfunction, porphyria, or known hypersensitivity to this drug prohibits its use.
adverse effects The most serious adverse effects are blood dyscrasias. Headache, GI symptoms, and rashes also may occur.

griseofulvin

Microbiology An oral antifungal with an affinity for skin, used to treat dermatophytoses–eg, Epidermophyton spp, Microsporum spp, Trichophyton spp Adverse effects Headache, N&V, diarrhea, photosensitivity, fever, rash, dysfunction of hepatic, CNS, hematopoietic systems; it is teratogenic and carcinogenic in rodents. Cf Amphotericin B.

gris·e·o·ful·vin

(gris'ē-ō-ful'vin)
A fungistatic agent used in the systemic treatment of superficial fungal infections caused by certain dermatophytes, which inhibits microtubule assembly.

griseofulvin

An antifungal drug derived from a Penicillium mould that concentrates in the outer layers of the skin and in the nails and is thus useful in the treatment of ‘ringworm’ (TINEA) infections. Skin infections settle quickly, but tinea of the nails requires treatment for months. Brand names are Fulcin and grisovin.

griseofulvin

systemic antifungal agent used to treat widespread or intractable skin dermatophyte infections and onychomycosis; contraindicated in patients with severe liver disease, systemic lupus erythematosus, porphyria, pregnant and lactating women and infants; use has been largely superseded by newer antifungal agents, e.g. terbinafine; griseofulvin spray (400 μg puffs to a maximum of 1.2 mg/day) is an effective topical treatment for tinea pedis

gris·e·o·ful·vin

(gris'ē-ō-ful'vin)
A fungistatic antibiotic produced by Penicillium species; used in systemic treatment of superficial fungal infections.

griseofulvin

a fungistatic antibiotic produced by Penicillium griseofulvum used orally for treatment of fungal infections of the skin. Toxic effects include bone marrow suppression and teratogenicity.
References in periodicals archive ?
These gene expression profiles then were used to produce a molecular map of pathologic change and griseofulvin exposure in this system.
Microscopic examination showed the pathologic change induced by griseofulvin was more apparent in C57BL/6J mice than in BALB/c mice (Figure 1).
At 24 weeks, terbinafine increased the likelihood of mycologic cure compared with griseofulvin (RR = 1.
In this Novartis-sponsored review, the dermatologist scrutinized the 11 published studies having outcome data at 18 months or more of follow-up for therapies using terbinafine, itraconazole, griseofulvin, fluconazole, and ketoconazole.
Long-Term Outcomes of Oral Agents for Onychomycosis Mycologically negative 18 Treatment months after start of therapy Terbinafine at 250 mg/day 62% for 12-16 weeks Fluconazole at 450 mg once 49% weekly for up to 1 year Griseofulvin at 1 g/day 43% for 1 year Itraconazole at 200 or 400 mg/day 37% for 1 week per month for 3-4 months Ketoconazole at 200 mg/day 11% for up to 1 year Source: Dr.
Griseofulvin Oral Suspension USP, the generic equivalent of Ortho-McNeil's Grifulvin(R) V, will be available in the 125mg/5mL strength.
Annual sales of Griseofulvin Oral Suspension USP in the U.
manufacturer of GRIFULVIN V(R) and griseofulvin oral suspension, which has a Patriot Pharmaceuticals, L.
or COMP COMP 500MG GRISEOFULVIN RECUB / GREATER THAN 2 YEARS MATURITY
5 mg,Tab Clomiphene citrate,Tab Griseofulvin 125 mg.
The only medication currently indicated for the treatment of tinea capitis is griseofulvin, which has been the standard of treatment for the condition for nearly 40 years.
In addition to cimetidine, Warrick's current product lines include the anti-asthma drugs albuterol and theophylline, the antifungals clotrimazole and griseofulvin, and the antipsychotic drug perphenazine.