Other fluoroquinolones such as gemifloxacin, sparfloxacin, grepafloxacin
, trovafloxacin, and garenoxacin have been shown to be effective against M.
Comparative antimycobacterial activities of ofloxacin, ciprofloxacin and grepafloxacin
14,15) A study by Yamaguchi et al16 demonstrated that both grepafloxacin
and levofloxacin undergo intestinal secretion via P-glycoprotein, and it was evidenced by decreases in their bioavailability when co-administered with the P-glycoprotein inhibitor cyclosporine.
aureus F265 has also been reported to have increased resistance to nalidixic acid, ciprofloxacin, moxifloxacin, trovafloxacin, grepafloxacin
, levofloxacin and ofloxacin, compared to S.
Sparfloxacin and grepafloxacin
were the most potent inhibitors of the HERG channel, with 50% inhibitory concentration ([IC.
Serious adverse drug effects in patients led to the withdrawal or restriction of four quinolones in the past decade (temafloxacin, grepafloxacin
, trovafloxacin, and sparfloxacin).
Some of the fluoroquinolones in the studies are no longer routinely used for safety reasons, such as trovafloxacin (Trovan), which is not used in community-acquired pneumonia, and grepafloxacin
, which is off the market.
Newer fluoroquinolones with higher in vitro activity against the pneumococcus, including levofloxacin, grepafloxacin
, gatifloxacin, and moxifloxacin, are available in the United States.
Concerns about potential QT interval prolongation have prompted Glaxo Wellcome to voluntarily withdraw its quinolone, grepafloxacin
, from the market.
Tatsuo Higuchi; Phone +81-3-3292-0021) and GlaxoSmithKline plc (GSK) have resolved their longstanding dispute relating to the then Glaxo Wellcome's voluntary withdrawal from the market in October 1999 of grepafloxacin
(generic name; trade names - RAXAR and VAXAR) by way of compensation payment by GSK to Otsuka.
Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin
, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model.