Grenz zone | definition of grenz zone by Medical dictionary
in histopathology, a narrow layer beneath the epidermis that is not infiltrated or involved in the same way as are the lower layers of the dermis.
[Ger. Grenze, borderline, boundary] A well-demarcated zone of separation in the upper dermis delineated by the collagen of the flattened basal epidermis from the upper dermis, the latter of which often has a dense, usually lymphocytic infiltrate. A grenz zone is seen in granuloma faciale, lepromatous leprosy, and lymphocytoma cutis and may separate a pilar tumour or leiomyoma from atrophic overlying skin
a zone of relatively normal collagen demarcating the boundary between normal epidermis and a dermal lesion such as a granuloma or a neoplasm.
References in periodicals archive
Biopsies showed increased Grenz zone
collagen, as well as increased staining for mRNA for type I collagen.
Results showed a 50-80% increase in Grenz zone
collagen (upper dermal collagen) in two of the three formulations designed to optimize growth factor penetration.