Gray baby syndrome | definition of gray baby syndrome by Medical dictionary
gray baby syndrome
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gray syndrome [gra]
a potentially fatal condition seen in neonates, particularly premature infants, due to a reaction to chloramphenicol
, characterized by an ashen gray cyanosis, listlessness, weakness, and hypotension. Called also gray baby syndrome
gray syn·drome , gray baby syndrome
gray appearance of an infant at birth and during the neonatal period that can be caused by transplacental toxic effects of the drug chloramphenicol taken by the mother during late pregnancy; the syndrome may be fatal.A condition that may occur when chloramphenicol levels exceed 70 µg/mL; premature infants are most susceptible, given their limited capacity to glucuronidate and excrete chloramphenicol, the functional deficiency in glucuronyl transferase activity corrects itself within the first 3–4 wks of life; high levels of chloramphenicol inhibit mitochondrial electron transport, disrupting energy metabolism; in children < 1 month of age, doses should be 25 mg/kg
Lab Clourimetry, GLC, HPLC, microbiologic, radioenzymatic methods
gray syn·drome , gray baby syndrome (grā sin'drōm, bā'bē)
Ashen appearance of an infant at birth and during the neonatal period that can be caused by transplacental toxic effects of the drug chloramphenicol taken by the mother during late pregnancy; the syndrome may be fatal.
References in periodicals archive
Chloramphenicol is capable of causing severe side effects in humans, including in rare cases aplastic anemia and gray baby syndrome
(another name for chloramphenicol toxicity in new-borns, the often-fatal result of giving newborns the drug for bacterial infection).