grapefruit juice


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Bariatric medicine A citrus fruit said to induce extreme weight loss
Nutrition A citrus fruit which has long been regarded as a healthy food

grapefruit juice

A drink derived from a fruit rich in chemicals called flavonoids, which impair the metabolism of drugs processed by the liver's cytochrome P 450 system.

CAUTION!

Patients should be advised that the juice alters the metabolism of several important drugs, including warfarin, steroids, calcium channel blockers, statins, second-generation antihistamines, protease inhibitors, and others.
See also: juice
References in periodicals archive ?
Lilja et al (16) conducted a randomized, 4-phase, crossover study to look at the effect of grapefruit juice dose on kinetics of triazolam.
At the end of the study period, the mice that ate the high-fat diet and drank diluted grapefruit juice not only gained less weight than their control counterparts, they also had a 13 to 17 percent decrease in blood glucose levels and a threefold decrease in insulin levels, which reveals greater sensitivity to insulin.
Always ask the pharmacist if there are foods - including grapefruit or grapefruit juice - that should be avoided while taking the medication.
The active ingredients responsible for interactions of grapefruit juice with medication are not clearly identified.
Instead, we wanted to see if grapefruit juice could be used in a controlled fashion to increase the availability and efficacy of sirolimus.
Cohen and his coauthors conducted three trials with 138 cancer patients, who either received just sirolimus, sirolimus and ketoconazole - another drug that can also slow the body's breakdown of sirolimus - or sirolimus and grapefruit juice.
Since grapefruit juice is reported to inhibit P-gp function, this study investigated the effect of the juice on the transport of CoQ10 by Caco-2 cells (a cell line used to model the lining of the human intestine).
Grapefruit juice contains three main furanocomarins.
Falling global inventories of orange juice and Florida inventories of grapefruit juice also will exert upward pressure on 2009-10 farm prices, according to Mark Brown, senior research economist at the Florida Department of Citrus.
A freshly squeezed pink grapefruit juice added a jolt of colour to our table as my dining partner and I picked our dishes from the one-page menu.
Grapefruit juice can increase blood levels of certain drugs three to five times, said study director Ezra Cohen, cancer specialist at the UCMC.
But it didn't get full respect until the 1960s, when fresh-squeezed grapefruit juice began to appear in restaurants.