grapefruit juice


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Bariatric medicine A citrus fruit said to induce extreme weight loss
Nutrition A citrus fruit which has long been regarded as a healthy food

grapefruit juice

A drink derived from a fruit rich in chemicals called flavonoids, which impair the metabolism of drugs processed by the liver's cytochrome P 450 system.

CAUTION!

Patients should be advised that the juice alters the metabolism of several important drugs, including warfarin, steroids, calcium channel blockers, statins, second-generation antihistamines, protease inhibitors, and others.
See also: juice
References in periodicals archive ?
The researchers gave one group of mice naringin, a bioactive compound in grapefruit juice that has been identified as a key agent in weight loss, and another group metformin, a glucose-lowering drug often prescribed for those with Type 2 diabetes.
Although ketoconazole produced a slightly stronger drug-retention effect, grapefruit juice has the advantage that it is non-toxic, with no risk of overdose.
However, they noted that the effect of grapefruit juice on an individual patient may vary, and that they found that the clinical activity of canned grapefruit juice differed from frozen grapefruit concentrate.
The grapefruit juice phenomena can last for 24 hours, which means there may be no safe time to have these healthy drinks if you're taking any medication.
Mix orange or grapefruit juice with your favorite herbs and spices (such as black pepper, granulated garlic, fresh onion or onion powder, minced fresh ginger or powdered ginger, chopped fresh or dried parsley, or a commercial spice mix) in a plastic or glass bowl.
But there have been cases where the drug has interacted with grapefruit juice, increasing the chances of side effects.
Grapefruits and grapefruit juice contain a substance that increases the blood levels of some statins.
The effect is similar to that observed after consuming grapefruit juice with such drugs as statins and calcium channel blockers.
The new campaign emphasizes that grapefruit juice is fat-free, hydrating, packed with nutrients and tastes zingy on the tongue.
Bailey and Spence and colleagues at the University of Western Ontario (5) made the serendipitous discovery that grapefruit juice interferes with the metabolism of felodipine, a calcium channel blocking anti-hypertensive.
Compounds called furocoumarins in grapefruit juice increase the bioavailabiity of several drugs by interfering with enzyme activity in the small intestine.
The range is packed in Tetra Rex ScrewCap one litre canons, and consists of Florida Squeezed Orange Juice, Florida Orange Juice with Juicy Bits, Apple with mango Juice, Pressed Apple Juice, Pineapple Juice and Florida Pink Grapefruit Juice.