granulovacuolar degeneration


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gran·u·lo·vac·u·o·lar de·gen·er·a·tion

degeneration of hippocampal brain cells in old people, characterized by basophilic granules surrounded by a clear zone in hippocampal neurons; occurs more frequently in Alzheimer disease.

granulovacuolar degeneration

A pathological finding in the brain cells of some patients with Alzheimer's dementia in which the neuronal cytoplasm is partly replaced by cavities that contain particles resembling grit or sand.
See also: degeneration