granulosa cell tumor


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granulosa cell tumor

 [gran″u-lo´sah]
an ovarian tumor originating in the granulosa cells, the solid mass of cells surrounding the graafian follicle; it may be associated with excessive production of estrogen, inducing endometrial hyperplasia with menorrhagia.

gran·u·lo·sa cell tu·mor

a benign or malignant tumor of the ovary arising from the membrana granulosa of the vesicular ovarian (graafian) follicle and frequently secreting estrogen; it is soft, solid, white or yellow, and consists of small round cells sometimes enclosing Call-Exner bodies; larger lipid-containing cells may be present.
Synonym(s): folliculoma (1)

granulosa cell tumor

[gran′yoo͡lō′sə]
Etymology: L, granulum, little grain
a fleshy ovarian tumor with yellow streaks that originates in cells of the primordial membrana granulosa and may grow to a large size. Excessive production of estrogen, resulting in endometrial hyperplasia and menorrhagia, may be associated with the tumor. Also called granulosa cell carcinoma.

granulosa cell tumor

Gynecology A sex cord tumor of older ♀ that comprises 1-2% of ovarian neoplasms, which is 'driven' by unopposed estrogen stimulation; the endometrium of Pts with GCTs often has cystic hyperplasia and 5-25% of Pts also have a concomitant well-differentiated endometrial CA

gran·u·lo·sa cell tu·mor

(gran'yū-lō'să sel tū'mŏr)
A benign or malignant tumor of the ovary arising from the membrana granulosa of the ovarian (graafian) follicle and frequently secreting estrogen.
Synonym(s): folliculoma (1) .

granulosa cell tumor

an ovarian stromal tumor originating in the solid mass of cells (granulosa cells) that surrounds the ovum in a developing graafian follicle. It may be associated with excessive production of estrogen, inducing endometrial hyperplasia and signs of hyperestrogenism. Most commonly observed in cows and mares, less commonly in the bitch, queen and ewe.
Enlarge picture
Granulosa cell tumor in a mare's ovary atnecropsy. By permission from Knottenbelt DC, PascoeRR, Diseases and Disorders of the Horse, Saunders, 2003
References in periodicals archive ?
Congenital testicular juvenile granulosa cell tumor in a neonatal with X/XY mosaicism.
Malignant advanced granulosa cell tumor of the adult testis: case report and review of the literature," Human Pathology, vol.
7) Rare cases of neonatal abdominal juvenile granulosa cell tumors originating from from undescended testicles appear as well-circumscribed, multicystic and multiseptated masses.
Chen L, Yang B: 14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
EMA is used initially to exclude adenocarcinoma since granulosa cell tumor in negative for this marker.
5 adenocarcinoma) Malignant ovarian tumors 18 Granulosa cell tumor 7 Serous papillary 6 cystadenocarcinoma Mucinous papillary 2 5.
Management of granulosa cell tumors (including the juvenile subtype) begins with surgery for definitive tissue diagnosis, staging, and debulking.
Testicular granulosa cell tumor of adult type: a new case and a review of the literature.
Leontiasis ossea, slipped epiphyses, and granulosa cell tumor ofthe testis with renal disease: report of a case with autopsy findings.
Reference Diagnoses (Correct General Classification, %)a Reference Category N Correlation, % Benign cysts 22 100 Endometriosis 5 100 Leiomyoma 1 100 Fibroma 3 100 Benign lesion, NOS 3 100 Brenner tumor 1 100 Borderline tumor 5 60 Granulosa cell tumor 2 100 Invasive carcinoma 10 100 Total 52 96 Total benign 34 100 Total malignant/BL/UNC 18 89 Abbreviations: BL, borderline; NOS, not otherwise specified; UNC, uncertain malignant potential.
Inhibin A identifies steroid-producing cells, and thus is a sensitive marker for ACC, ovarian granulosa cell tumor, and testicular Sertoli-Leydig cell tumor.
Testicular granulosa cell tumor of the adult type is a very rare tumor, and to date, only a small number of cases have been reported.