| granulosa cell tumor n. A benign or malignant tumor of the ovary developing from the granular layer of the Graafian follicle and frequently secreting estrogen. Also called folliculoma. |
granulosa cell tumor
[gran′yoo͡lō′sə]
Etymology: L, granulum, little grain
a fleshy ovarian tumor with yellow streaks that originates in cells of the primordial membrana granulosa and may grow to a large size. Excessive production of estrogen, resulting in endometrial hyperplasia and menorrhagia, may be associated with the tumor. Also called granulosa cell carcinoma.
granulosa cell tumor
an ovarian stromal tumor originating in the solid mass of cells (granulosa cells) that surrounds the ovum in a developing graafian follicle. It may be associated with excessive production of estrogen, inducing endometrial hyperplasia and signs of hyperestrogenism. Most commonly observed in cows and mares, less commonly in the bitch, queen and ewe.
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Granulosa cell tumor in a mare's ovary atnecropsy. By permission from Knottenbelt DC, PascoeRR, Diseases and Disorders of the Horse, Saunders, 2003
granulosa cell tumor
Gynecology A sex cord tumor of older ♀ that comprises 1-2% of ovarian neoplasms, which is 'driven' by unopposed estrogen stimulation; the endometrium of Pts with GCTs often has cystic hyperplasia
and 5-25% of Pts also have a concomitant well-differentiated endometrial CA
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