granulomatous colitis

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gran·u·lom·a·tous co·li·tis

changes, identical to those of regional enteritis, involving the colon.

gran·u·lom·a·tous co·li·tis

(gran'yū-lom'ă-tŭs kŏ-lī'tis)
Changes, identical to those of regional enteritis, involving the colon.


pl. colitides; inflammation of the colon. There are many types of colitis, each having different etiologies. The differential diagnosis involves the clinical history, fecal examinations, proctoscopy, radiological studies such as barium enemas, and sometimes biopsy.

antibiotic-associated colitis
colitis associated with antimicrobial therapy occurs in humans and animals. It can range from mild nonspecific colitis and diarrhea to severe fulminant pseudomembranous colitis (see below) with profuse watery diarrhea. The inflammation may be caused by a toxin produced by Clostridium difficile, a microorganism that is not normally present in the resident bowel flora. Presumably, the disruption of the normal flora allows the growth of C. difficile. There is developing evidence that, in foals and adult horses, C. difficile can be associated with diarrheal disease that can vary from mild to self-limiting to an acute and fatal enterocolitis. Evidence for this association is the biological plausibility, some evidence that this syndrome can be reproduced experimentally, and the ability to demonstrate the organism or its toxin in the feces of horses with the enterocolitis in comparison with the low prevalence and absence of toxin in the feces of non-diarrheic horses. This syndrome commonly occurs in horses following antimicrobial therapy and/or hospitalization. It is possible that enterotoxin from intestinal C. perfringens may also contribute in horses and the syndrome has been called equine clostridiosis.
ciliate colitis
colitis in primates caused by Troglodytella spp. and characterized by diarrhea.
colitis cystica profunda
dilated, grossly visible colonic glands protrude through the muscularis mucosae into the submucosa; no specific cause attributed; an incidental necropsy finding, especially in pigs.
eosinophilic ulcerative colitis
occurs in humans and dogs, either as a primary disease or as part of an eosinophilic gastroenteritis. Characterized histologically by eosinophilic infiltration of the lamina propria and submucosa. May be caused by hypersensitivity reactions, parasites or foreign body reactions.
granulomatous colitis
see histiocytic ulcerative colitis (below).
histiocytic ulcerative colitis
a chronic, debilitating inflammation of the colon occurring predominantly in young Boxer dogs. Affected dogs have a chronic hemorrhagic diarrhea with tenesmus, and occasionally vomiting, inappetence and weight loss. Colonic mucosa is thickened, friable and ulcerated. Macrophages containing PAS-positive granules are found in the mucosa and submucosa. The cause of this disease is unknown. It is similar, but not identical to, ulcerative colitis, granulomatous colitis and Whipple's disease of humans.
idiopathic colitis
a disease similar to histiocytic ulcerative colitis (above), occurring predominantly in dogs other than Boxers and lacking the PAS-positive granules in histiocytes.
mucous colitis
see irritable colon syndrome.
plasmacytic-lymphocytic colitis
mucosal infiltration by plasmacytes and lymphocytes associated with sign of colitis in dogs. Dietary hypersensitivity is considered an important cause.
pseudomembranous colitis
a severe acute inflammation of the bowel mucosa, with the formation of pseudomembranous plaques. It is most commonly associated with antimicrobial therapy (see antibiotic-associated colitis (above)). Called also pseudomembranous enterocolitis.
psychologically induced colitis
see irritable colon syndrome.
uremic colitis
an outstanding lesion in cattle dying of uremia.
a peracute colitis of horses, sometimes occurring as outbreaks, characterized by a short course of about 24 hours, profuse diarrhea, sometimes with colic and dysentery and profound dehydration. The cause is unknown and the outcome invariably fatal.


composed of granulomas.

granulomatous colitis
see histiocytic ulcerative colitis.
granulomatous encephalitis
see granulomatous meningoencephalomyelitis.
granulomatous enteritis
see granulomatous enteritis.
equine generalized granulomatous disease
a generalized disease affecting skin and all internal organs and of unknown origin; characterized by exfoliative dermatitis, wasting, and granulomatous lesions internally; skin lesions are dermal granulomatous nodules plus superficial exfoliation.
granulomatous meningoencephalomyelitis
see granulomatous meningoencephalomyelitis.
granulomatous perineuritis
granulomatous rhinitis
see enzootic nasal granuloma.
granulomatous skin disease
see granular dermatitis.
granulomatous synovitis/arthritis
lesion characterized by granulomatous tissue on the synovial surface of the bones in the joint; may occur in systemic mycotic infections.
granulomatous urethritis
see granulomatous urethritis.
References in periodicals archive ?
1) We herein report an unusual case of granulomatous colitis associated with botryomycosis of P acnes.
Although further cases and pathologic changes need to be analyzed in more detail, P acnes should be considered as one of the causative microorganisms of granulomatous colitis.

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