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granulomatous amebic encephalitis

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granulomatous amebic encephalitis,
chronic encephalitis, usually seen in debilitated or immunocompromised patients, caused by infection with species of Acanthamoeba. It is marked by the formation of granulomas. Headache, seizures, nausea, and vomiting frequently occur.


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These protozoa have been implicated in local infections, such as amebic keratitis, mainly in immunocompetent contact lens wearers, and in the mostly fatal, granulomatous amebic encephalitis in immunocompromised patients with HIV/ AIDS and immunosuppressant-treated patients, including organ transplant recipients (2-4).
Infection with Acanthamoeba, a free-living ameba, is a rare cause of slowly progressive granulomatous amebic encephalitis (GAE) in immunocompromised patients.
Inability to make a premortem diagnosis of Acanthamoeba species infection in a patient with fatal granulomatous amebic encephalitis.
 
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