granulation tissue

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Related to granulation tissue: granuloma


a group or layer of similarly specialized cells that together perform certain special functions.
adenoid tissue lymphoid tissue.
adipose tissue connective tissue made of fat cells in a meshwork of areolar tissue.
areolar tissue connective tissue made up largely of interlacing fibers.
bony tissue osseous tissue.
brown adipose tissue (brown fat tissue) brown fat.
bursa-equivalent tissue (bursal equivalent tissue) a hypothesized lymphoid tissue in nonavian vertebrates including human beings, equivalent to the bursa of Fabricius in birds: the site of B lymphocyte maturation. It now appears that B lymphocyte maturation occurs primarily in the bone marrow.
cancellous tissue the spongy tissue of bone.
cartilaginous tissue the substance of cartilage.
chordal tissue the tissue of the notochord.
chromaffin tissue a tissue composed largely of chromaffin cells, well supplied with nerves and vessels; it occurs in the adrenal medulla and also forms the paraganglia of the body.
cicatricial tissue the dense fibrous tissue forming a cicatrix, derived directly from granulation tissue; called also scar tissue.
connective tissue the tissue that binds together and is the support of the various structures of the body; see also connective tissue.
elastic tissue connective tissue made up of yellow elastic fibers, frequently massed into sheets.
endothelial tissue peculiar connective tissue lining serous and lymph spaces.
epithelial tissue a general name for tissues not derived from the mesoderm.
erectile tissue spongy tissue that expands and becomes hard when filled with blood.
fatty tissue connective tissue made of fat cells in a meshwork of areolar tissue.
fibrous tissue the common connective tissue of the body, composed of yellow or white parallel elastic and collagen fibers.
gelatinous tissue mucous tissue.
granulation tissue material formed in repair of wounds of soft tissue, consisting of connective tissue cells and ingrowing young vessels; it ultimately forms cicatrix.
gut-associated lymphoid tissue (GALT) lymphoid tissue associated with the gut, including the tonsils, Peyer's patches, lamina propria of the gastrointestinal tract, and appendix.
indifferent tissue undifferentiated embryonic tissue.
interstitial tissue connective tissue between the cellular elements of a structure.
lymphadenoid tissue tissue resembling that of lymph nodes, spleen, bone marrow, tonsils, and lymph vessels.
lymphoid tissue a latticework of reticular tissue whose interspaces contain lymphocytes.
mesenchymal tissue embryonic connective tissue composed of stellate cells and a ground substance of coagulable fluid.
mucous tissue a jellylike connective tissue, such as occurs in the umbilical cord. Called also gelatinous tissue.
muscular tissue the substance of muscle.
myeloid tissue red bone marrow.
nerve tissue (nervous tissue) the specialized tissue forming the elements of the nervous system.
osseous tissue the specialized tissue forming the bones.
reticular tissue (reticulated tissue) connective tissue composed predominantly of reticulum cells and reticular fibers.
scar tissue cicatricial tissue.
sclerous t's the cartilaginous, fibrous, and osseous tissues.
skeletal tissue the bony, ligamentous, fibrous, and cartilaginous tissue forming the skeleton and its attachments.
splenic tissue red pulp.
subcutaneous tissue the layer of loose connective tissue directly under the skin.
tissue typing identification of tissue types for purposes of predicting acceptance or rejection of grafts and transplants. The process and purposes of tissue typing are essentially the same as for blood typing. The major difference lies in the kinds of antigens being evaluated. The acceptance of allografts depends on the hla antigens (HLA); if the donor and recipient are not HLA identical, the allograft is rejected, sometimes within minutes. The HLA genes are located in the major histocompatibility complex, a region on the short arm of chromosome 6, and are involved in cell-cell interaction, immune response, organ transplantation, development of cancer, and susceptibility to disease. There are five genetic loci, designated HLA-A, HLA-B, HLA-C, HLA-D, and HLA-DR. At each locus, there can be any of several different alleles.

Each person inherits one chromosome 6 from the mother and one from the father; that is, each parent transmits to the child one allele for each kind of antigen (A, B, C, D, and DR). If the parents are different at both alleles of a locus, the statistical chance of one sibling being identical to another is one in four (25 per cent), the chance of being identical at one allele only (half-identical) is 50 per cent, and the chance of a total mismatch is 25 per cent.
Techniques for Tissue Typing. Histocompatibility testing involves several basic methods of assay for HLA differences. The most widely used method uses the polymerase chain reaction to compare the DNA of the person, organ, or graft being tested with known pieces of the genes encoding MHC antigens. The variability of these regions of the genes determines the tissue type of the subject.

Serologic methods are used to detect serologically defined antigens on the surfaces of cells. In general, HLA-A, -B, and -C determinants are primarily measured by serologic techniques. A second method, involving lymphocyte reactivity in a mixed lymphocyte culture, for determining HLA-D or lymphocyte-defined antigens, is now only rarely used.

Essentially, the serologic method is performed by incubating target lymphocytes (isolated from fresh peripheral blood) with antisera that recognize all known HLA antigens. The cells are spread in a tray with microscopic wells containing various kinds of antisera and are incubated for 30 minutes, followed by an additional 60-minute complement incubation. If the lymphocytes have on their surfaces antigens recognized by the antibodies in the antiserum, the lymphocytes are lysed. A dye is added to show changes in the permeability of the cell membrane and cellular death. The proportion of cells destroyed by lysis indicates the degree of histologic incompatibility. If, for example, the lymphocytes from a person being tested for HLA-A3 are destroyed in a well containing antisera for HLA-A3, the test is positive for this antigen group.
white adipose tissue (yellow adipose tissue) the adipose tissue composing the bulk of the body fat.

gran·u·la·tion tis·sue

vascular connective tissue forming granular projections on the surface of a healing wound, ulcer, or inflamed tissue surface.
See also: granulation.

granulation tissue

Etymology: L, granulum, little grain
any soft pink fleshy projections that form during the healing process in a wound that does not heal by primary intention. The tissue consists of many capillaries surrounded by fibrous collagen. Overgrowth of granulation tissue causes proud flesh growing above the skin. See also pyogenic granuloma.
enlarge picture
Granulation tissue

granulation tissue

A post-inflammatory reaction characterized by edema, chronic inflammation–lymphocytes, macrophages, plasma cells, and proliferating endothelial cells and blood vessels

gran·u·la·tion tis·sue

(gran'yū-lā'shŭn tish'ū)
Vascular connective tissue forming granular projections on the surface of a healing wound, ulcer, or inflamed surface.
See also: granulation

granulation tissue

The tissue that forms on a raw surface or open wound in the process of healing. It consists of rapidly budding new blood capillaries surrounded by newly generated COLLAGEN fibrils secreted by cells called FIBROBLASTS, and many embedded inflammatory cells.

Granulation tissue

A kind of tissue formed during wound healing, with a rough or irregular surface and a rich supply of blood capillaries.
Mentioned in: Granuloma Inguinale

granulation tissue

capillary aggregations at the surface of a wound, ulcer or inflamed tissue, as the result of neovascularization; part of healing by secondary intention

gran·u·la·tion tis·sue

(gran'yū-lā'shŭn tish'ū)
Vascular connective tissue forming granular projections on the surface of a healing wound, ulcer, or inflamed surface.

granulation tissue,

n a soft, pink, fleshy projections that form during the healing process in a wound not healing by first intent. It consists of many capillaries surrounded by fibrous collagen. Overgrowth is termed
proud flesh. In dentistry, such tissue is evident at the opening to a fistulous tract or at the site of a recent tooth extraction.


1. the division of a hard substance into small particles.
2. the formation in wounds of small, rounded masses of tissue during healing; also the mass so formed.

arachnoid g's
enlarged arachnoid villi projecting into the venous sinuses and creating slight depressions on the inner surface of the cranium.
exuberant g's
excessive proliferation of granulation tissue in the healing of a wound.
granulation tissue
the new tissue formed in repair of wounds of soft tissue, consisting of connective tissue cells and ingrowing young vessels. It ultimately forms the cicatrix; excessive granulation is a common cause of chronic failure of wounds on the lower limbs of horses to heal.
References in periodicals archive ?
1) The diagnosis of MOE is made using patient history, the presence of granulation tissue in the EAC, an elevated erythrocyte sedimentation rate, and increased uptake in the temporal bone on nuclear imaging.
The higher concentration of hexosamine content in the initial stage of repair could be attributed to its nonutilisation since granulation tissue was being laid down.
Ingrown toenails could be a cause of granulation tissue of the lateral nail fold of the finger or toe (1).
A2: young vessel-rich granulation tissue (slim arrow), fibrin, inflammatory cells and necrotic tissue debris.
Criteria include: refractory otitis externa, severe nocturnal otalgia and purulent otorrhea associated with Pseudomonas infection and granulation tissue in an immunocompromised or diabetic patient.
In root fracture cases there are two objectives, firstly to achieve the union of two fragments (without granulation tissue interposing in between them) and secondly leave the apical root fragment in situ in the alveolus as it helps to maintain the bone height and remains vital.
However, another aspect of molecular dysfunction is an inability to induce stable granulation tissue.
Sometimes the granulation tissue contains inflammatory cells, eg, macrophages, plasma cells, and neutrophils with eosinophilia.
A bronchoscopy showed a band of tissue in the subglottic area and a granulation tissue mass in the adjacent area functioning as a ball valve causing obstruction.
Nagi warned that subungual melanoma is often asymptomatic and that up to 25% of cases can be amelanotic, so it is easily mistaken for pyogenic granuloma, chronic granulation tissue, or mycobacterial infection with nail dystrophy
Fibroblastic phase, where new blood vessels and tissue, which is called granulation tissue, are laid down.
The studies she presented covered microvascular blood flow using various negative pressures and wound fillers, tissue in-growth, force required to remove foam versus gauze, pressure transduction, macro and microdeformation (mechanical effects of NPWT), granulation tissue characteristics, wound bed histology, and measurement of neuropeptides as signals of pain during dressing changes.