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Rapid pathogen ID from blood cultures, early initiation of susceptibility tests, and clinical interventions supported by effective communication and interpretation of this vital data have resulted in reduced length of stay, lower mortality, and lower costs for cases of Gram-negative bacteremia at a major U.
The Methodist Hospital team effort quality improvement example for treating Gram-negative bacteremia can support the case for investing in and implementing rapid microbiology methods in any laboratory--for both medical and financial reasons.
25-27) Gram-negative bacteremia was used as the gold standard in all the studies.
35) Here, the question was whether the type of gram-negative bacteremia detected, either an Enterobacteriaceae type or not, was an important factor in the ability of the assay to detect endotoxemia, a question that no single study had been large enough to address.
However, the data analysis presented in Table 3 is an attempt at focusing on those studies which have study designs that most closely resemble a `real-life' use of the assay to detect gram-negative bacteremia in patients with suspected bacteremia.
Concordance of endotoxaemia with gram-negative bacteremia in patients with gram-negative sepsis: a meta-analysis.
Endotoxins have a direct suppressant effect on myocardial contractility, and myocardial dysfunction can occur in patients infected with gram-negative bacteremia.
Other topics include the endothelium as a target for infections, genetic regulation of congenital heart disease, lung cancer preneoplasia, calcium in cell injury, the genetics of soft tissue tumors, and the role of gram-negative bacteremia in sepsis.
Failure of the LAL assay to correlate with gram-negative bacteremia in patients with sepsis has recently been documented (6).
Catheter-associated urinary tract infections can lead to such complications as prostatitis, epididymitis, cystitis, pyelonephritis and gram-negative bacteremia (infection of the blood), resulting in increased risk for patients and longer hospital stay.
About one-third of those diagnosed with this microbial poisoning, called gram-negative bacteremia, die from the infection despite massive doses of antibiotics, which kill the offending bacteria but leave the endotoxin intact.
In the 200 patients with gram-negative bacteremia, infection-related mortality was 39 percent lower among those receiving HA-1A than among those on placebo.

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