graft rejection


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Related to graft rejection: Graft versus host disease

graft rejection

the immunological destruction of transplanted organs or tissues. The rejection may be based on both cell-mediated and antibody-mediated immunity against cells of the graft by a histoincompatible recipient. First-set rejection usually occurs within 10 days. Second-set rejection occurs within 1 week after a second graft with the same antigenic specificity as the first is placed in the same host.

graft rejection

Rejection Clinical immunology The constellation of defenses mounted by the immune system of the recipient of an allograft–eg kidney, liver, pancreas, etc, which compromise the continued viability of grafted tissue. See Graft.

graft

1. any tissue or organ for implantation or transplantation.
2. to implant or transplant such tissue. See also flap (1), grafting, allograft, xenograft.

autodermic graft, autoepidermic graft
a skin graft taken from the patient's own body.
autologous graft, autoplastic graft
a graft taken from another area of the patient's own body; an autograft.
avascular graft
a graft of tissue in which not even transient vascularization is achieved.
graft bed
site to which a graft is to be joined.
bone graft
the transfer of living bone, usually for fracture repair or reconstructive surgery. Various types of bone grafts are identified, depending on their source and treatment, if any, e.g. cortical, autograft, allograft, cancellous, xenograft, isograft.
cable graft
a nerve graft made up of several sections of nerve in the manner of a cable.
chess-board graft
see stamp graft (below).
cutis graft
dermal graft.
dermal graft, dermic graft
skin from which epidermis and subcutaneous fat have been removed, used instead of fascia in various plastic procedures.
graft enhancement
prior exposure of the recipient to the donor's tissues may prolong survival of a graft.
epidermal graft
a piece of epidermis implanted on a raw surface.
fascia graft
a graft of tissue taken from the external investing fascia of the leg (fascia lata).
fascicular graft
a nerve graft in which bundles of nerve fibers are approximated and sutured separately.
free graft
a graft of tissue completely freed from its bed, in contrast to a flap.
full-thickness graft
a skin graft consisting of the full thickness of the skin, with little or none of the subcutaneous tissue.
heterodermic graft
heterologous graft, heteroplastic graft
a graft of tissue transplanted between animals of different species; a heterograft or xenograft.
homologous graft
a graft of tissue obtained from the body of another animal of the same species but with a genotype differing from that of the recipient; a homograft or allograft.
isologous graft, isoplastic graft
a graft of tissue transplanted between genetically identical individuals; an isograft.
lamellar graft
replacement of the superficial layers of an opaque cornea by a thin layer of clear cornea from a donor eye.
mesh graft
skin grafts in which multiple small incisions have been made to permit lateral stretching of the graft and to increase flexibility to facilitate placement in tricky sites.
Enlarge picture
Mesh graft. By permission from Slatter D, Textbookof Small Animal Surgery, Saunders, 2002
omental g's
free or attached segments of omentum used to cover suture lines following gastrointestinal or colonic surgery.
patch graft
used in the surgical repair of tissue defects of the esophagus and to enlarge the pulmonary outflow tract. In-lay patches replace missing tissue. On-lay patches reinforce existing tissue.
pedicle graft
a portion of skin and subcutaneous tissue with a vascular attachment moved from one part of the body to another. Grafted to the new site, they not only can survive because of their own vascular supply, they can improve circulation in the site. Called also pedicle flap.
penetrating graft
a full-thickness corneal transplant.
periosteal graft
a piece of periosteum to cover a denuded bone.
pinch graft
a piece of skin graft about 6 mm in diameter, obtained by elevating the skin with a needle and slicing it off with a knife.
punch graft
grafts are obtained by using a skin biopsy punch on the animal or on a piece of separated skin.
graft rejection
seed graft
small pieces of skin are imbedded in granulation tissue on the same patient.
sieve graft
a skin graft from which tiny circular islands of skin are removed so that a larger denuded area can be covered, the sievelike portion being placed over one area, and the individual islands over surrounding or other denuded areas.
skin graft
a piece of skin implanted to replace a lost part of the integument. Many types of graft are used and are included in this list.
split-skin graft
a skin graft consisting of only a portion of the skin thickness.
sponge graft
a bit of sponge inserted into a wound to promote the formation of granulations.
stamp graft
squares of split-thickness or full-thickness skin are placed on a bed of granulation tissue.
thick-split graft
a skin graft cut in pieces, often including about two-thirds of the full thickness of the skin.
tubed graft
see rope flap.
tunnel graft
see rope flap.
vascular graft
see vascular conduit.
References in periodicals archive ?
Therefore, it is possible to hatch chicks following somitic manipulations without the problem of species-specific graft rejection (Kinutani and Le Douarin, 1985).
A snapshot of the global therapeutic scenario for Corneal Graft Rejection.
In the present study beside 6 cases of graft rejection, there were 4 cases of wound infection, 6 of them had postoperative vertigo, 5 patients suffered from disturbances in taste sensation post operatively and 2 cases had sensorineural hearing loss.
As next steps, researchers will need to confirm that the findings are consistent in humans and also will investigate how exactly maternal T cells cause a graft rejection.
Serum enzymes such as amylase and lipase lack sufficient specificity or sensitivity to serve as sole markers for ACR (5), and recurrent hypoglycemia is a late consequence of graft rejection (6).
Graft rejection can be difficult to discern during pregnancy because serum creatinine levels are low during this period, and small changes can be missed, Dr.
Among the 14 failures, the graft was only partially taken up in 10 patients, which left a relatively large perforation that did not heal even after repeated cautery; the other four patients experienced a complete graft rejection because of gross sepsis in the middle ear.
In immune compromised individuals, such as transplant recipients or those with leukemia or HIV infection, CMV can cause serious life-threatening disease and may significantly increase the risk of graft rejection.
Postoperative Complications: Formation of double anterior chamber, Corneal stromal graft rejection, Recurrence of the original pathology, Graft dehiscence, Interface haze, Descemet's membrane folds.
They are used to detect HLA antibodies which may cause graft rejection.
1 When vessels are present on the cornea, the chances of graft rejection are very high, and it is considered a high-risk corneal graft surgery.
We re also doing basic science research to develop a new cell-based therapy to prevent graft rejection for both stem cell and solid organ transplantation.