grade IV astrocytoma


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grade IV as·tro·cy·to·ma

astrocytoma of high grade; World Health Organization designation.
See also: glioblastoma multiforme.

gli·o·blas·to·ma mul·ti·for·me

(glī'ō-blas-tō'mă mŭl'ti-fōr'mē)
A glioma consisting chiefly of undifferentiated anaplastic cells of glial origin that show marked nuclear pleomorphism, necrosis, and vascular endothelial proliferation; frequently, tumor cells are arranged radially about an irregular focus of necrosis; these neoplasms grow rapidly, invade extensively, and occur most frequently in the cerebrum of adults.
Synonym(s): grade IV astrocytoma.
[G. glia, glue, + blastos, germ, + -oma, tumor]
References in periodicals archive ?
Serum AHSG was [greater than or equal to]285 mg/L in 100% of control subjects, but only in 39% of grade II, 33% of grade III, and 22% of grade IV astrocytoma patients.
740-kDa peak size <22, whereas 15% of grade II, 40% of grade III, and 48% of grade IV astrocytoma patients did (Fig.
10) Microvascular proliferation (MVP), loosely defined to include endothelial hypertrophy, endothelial hyperplasia, and glomeruloid vessels, and/or necrosis are distinguishing features of WHO grade IV astrocytoma, the latter being synonymous with the commonly used term glioblastoma multiforme or simply glioblastoma (GBM) in the current WHO scheme.
Grade IV astrocytoma, GBM, is the most common type of glioma and has a survival time varying from less than 1 year to 3 years after initial diagnosis.
Grade IV astrocytoma is called glioblastoma, which has the highest degree of malignancy and also has an extremely poor prognosis.
GBM, also known as grade IV astrocytoma, is the most common and aggressive malignant brain tumor in adults.