gp120


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Related to gp120: CD4, CCR5

gp120

(jē′pē′wən-twĕn′tē)
n.
A glycoprotein that protrudes from the surface of the HIV virus and binds to the glycoprotein CD4 in human cells.

gp120

HIV A 120 kD glycoprotein on the surface of HIV-1, which binds to cells–T cells, macrophages at the CD4 receptor. See AIDS, AIDS vaccine, HIV.

gp120

A glycoprotein found on the outer surface of the HIV virus. It facilitates binding of the virus to CD4+ lymphocytes. Its molecular weight is 120 kD.
References in periodicals archive ?
All five of the protective clones generated by gp160 inoculation, he says, recognized the gp41 AIDS protein, but not the gp120.
Brenneman and his co-workers found that gp120 alone could bind and kill mouse neurons.
The "fusion protein" binds to cells expressing the gp120 protein, then sabotages their protein-making machinery.
Under the terms of the agreement, Trimeris will work with CRL to identify small molecule inhibitor compounds against two HIV entry targets, gp41 and gp120.
The first step in HIV entry takes place when glycoprotein "spikes," which include a protein called gp120 bind with the host cell receptor CD4.
Although gp120 is a naturally occurring substance, its isolation in 1984 by Harvard scientists made it patentable under current laws.
TNX-355 appears to prevent post-viral binding conformational changes in gp120, gp41, and/or CD4 needed for the virus to enter the cell.
The drugs are known to block glucosidase, which trims sugars from the HIV component gp120 during virus production in host cells.
We have amassed a database of full-length gp120 sequences from new infections representing HIV strains transmitted in the community today.
They have begun tests on rhesus monkeys to see if the protein, called gp120, will similarly prod a primate immune system into making the neutralizing antibodies.
The surface of HIV is naturally studded with envelope spikes that consist of three copies each of the gp120 and gp41 glycoproteins in a trimeric configuration.
The surface of HIV is naturally studded with envelope glycoprotein spikes that consist of three copies each of the gp120 and gp41 glycoproteins in a trimeric configuration.