gossypol


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gos·sy·pol

(gos'i-pol),
A toxic principle isolated from the seed of the cotton plant (Gossypium) that reduces sperm count; used in China as an oral male contraceptive.

gossypol

/gos·sy·pol/ (gos´ĭ-pol) a toxin found in cottonseed and detoxified by heating; it has male antifertility properties, apparently having its effects in the seminiferous tubules.

gossypol

An aromatic triterpene derived from cotton (Gossypum hirsutum) seed oil, which is 90% effective in reducing sperm counts to the level of infertility and thus flagged as a possible male contraceptive.
 
Cons
Nephrotoxicity, hypokalaemia; one-fourth become permanently sterile.

gos·sy·pol

(gos'i-pol)
(Gossypium hirsutum) This plant's parts are thought to be of value as a male contraceptive (clinical studies done); other uses are as an antineoplastic and vaginal spermicide. Adverse effects reported include heart failure, hepatotoxicity, nephrotoxicity, and, with oral ingestion of seeds, death by poisoning.
Synonym(s): cotton.
[gossypium, + -ol]

gossypol (gäˑ·s·pōl),

n Latin name:
Gossypium hirsutum; parts used: stalks, roots, seeds; uses: contraceptive, dysmenorrhea, labor inducer; precautions: pregnancy, lactation, children; patients with kidney and liver disease; can cause cardiac failure, nausea, diarrhea, muscle weakness, and paralysis. Also called
American upland cotton and
cotton.

gossypol

toxic phenolic pigment in the glands of seeds of gossypium spp.
References in periodicals archive ?
1]) 4173 4223 4324 Crude energy Lipideo (%) 2,35 1,53 2,31 Lipid Fibra bruta (%) 16,36 14,47 15,30 Crude fiber Gossipol livre (%) 0,0 0,0 0,0 Free gossypol Gossipol total (%) 0,10 0,10 0,18 Total gossypol Fosforo (%) 0,83 1,10 0,93 Phosphorus Calcio (%) 0,26 0,40 0,34 Calcium Ferro (mg [kg.
In further studies gossypol was shown to have anti-oxidant activity.
In further studies gossypol was also shown to have anti-oxidant activity.
A clinical trial of gossypol acetate involving men seeking vasectomy evaluated its efficacy, acceptability and side effects.
For example, cottonseed oil containing gossypol is such a potent inhibitor of sperm formation that entire regions of the province of Jiangsu in China produced no children while they were using the oil for cooking (61,62).
Plant drenches of salicylic acid at 61 and 123 [micro]M also increased cotton root gossypol concentration by 35 and 47%, respectively (Khoshkhoo et al.
One can and should question the higher fibre (11-13 per cent) and gossypol contents of cotton seed meal.
Pills, Implants, and Injectables for Males--the Gossypol pill is taken daily for 3 months followed by a pill 2-3 times a week.
Trials of Gossypol, our third oncology drug in development, and OLIGON, our FDA approved anti-infective biomaterial, will also benefit from the additional funding.
In addition, due to the different temperature and organic solvent used in cottonseed processing, there is also a big difference in the content of free gossypol which is the main anti-nutritional factor in cottonseed meal.
Menevse, The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index.