goserelin


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goserelin

 [go´sĕ-rel″in]
a synthetic gonadotropin-releasing hormone; upon administration it initially stimulates release of follicle-stimulating hormone and luteinizing hormone and on prolonged administration later suppresses them. It is used as the acetate salt to treat breast and prostate carcinomas and endometriosis and to thin the endometrium prior to endometrial ablation; administered by subcutaneous implant.

gos·er·e·lin

(gos'ĕr-ĕ-lin),
A synthetic decapeptide agonist analogue of LHRH (GnRH). It inhibits pituitary gonadotropin secretion and is used to treat prostate cancer, breast cancer, endometriosis, and for prethinning the endometrium before endometrial ablation or resection.

goserelin

/go·se·rel·in/ (go´sĕ-rel″in) a synthetic gonadotropin-releasing hormone; on prolonged administration it suppresses release of gonadotropins and is used as the acetate salt to treat breast and prostate carcinomas and endometriosis and to thin the endometrium prior to endometrial ablation.

goserelin

(gō′sə-rĕl′ĭn)
n.
A synthetic peptide analog of gonadotropin-releasing hormone used to treat prostate cancer, endometriosis, and advanced breast cancer.

gos·er·e·lin

(gō'sĕr-el'in)
A synthetic decapeptide agonist analogue of the luteinizing hormone-releasing hormone (GnRH); it inhibits pituitary gonadotropin secretion and is used in the treatment of prostate cancer, breast cancer, endometriosis, and for thinning the endometrium before endometrial ablation or resection.

goserelin

A gonadotrophin-releasing hormone used as a drug to treat ENDOMETRIOSIS, uterine FIBROIDS, MENORRHAGIA and cancer. A brand name is Zoladex.
References in periodicals archive ?
At the time of the first blood sample in November 2014, she was stable on everolimus, exemestane, goserelin, and zolendronic acid.
At 2 years, 22% of women receiving standard neoadjuvant or adjuvant chemotherapy alone and 8% of those receiving chemotherapy plus goserelin (Zoladex) experienced ovarian failure, defined as amenorrhea for the prior 6 months and follicle-stimulating hormone (FSH) in the postmenopausal range.
Findings of the study show that those who received AstraZeneca PLC's drug goserelin along with chemotherapy were 64 percent less likely to develop premature menopause than women who had chemotherapy alone and go on to have successful pregnancies.
Surprisingly, doctors also saw better survival among women given goserelin.
Abbott supplied the testosterone gel at no cost, and Astra Zeneca provided goserelin and anastrozole at no cost, but neither company played a role in study design, data analysis, data interpretation, or manuscript preparation.
The hormone therapy consisted of bicalutamide 50 mg/day for 1 month plus goserelin 10.
Participants first received goserelin to decrease mean endogenous testosterone levels to less than 50 nanograms per deciliter (ng.
A randomized controlled trial of goserelin and medroxyprogesterone acetate in the treatment of pelvic congestion.
Group A (22 patients) with adenomyosis received Gn-RHa alone, subcutaneous (SC) depot injections (inj) of goserelin (Zoladex, Zeneca, Cheshire, UK), 3.
The magnitude of BMD loss on goserelin was more pronounced with anastrozole than with tamoxifen but was effectively prevented by immediate administration of intravenous zoledronic acid.
I declined a prostate biopsy for an elevated PSA of 70 ng/mL (less than 4 ng/mL is normal), but he agreed to goserelin injections to treat the prostate cancer.