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good

Drug slang
noun A regional term for PCP or heroin.
 
Medspeak
adjective Referring to well-being, benefit.

leukemia

Hematology An uncommon–incidence, US 3.5/105/yr—malignant clonal expansion of myeloid or lymphoid cells characterized by an ↑ in circulating WBCs; leukemias may be an incidental finding when evaluating an unrelated clinical problem, or when the expansion compromises BM production of one or more cell lines causing anemia, thrombocytopenia, granulocytopenia; leukemias are divided by chronology–acute or chronic, by cell lineage–lymphoid, myeloid/myelocytic, monocytic or megakaryocytic and divided by stage of maturation or cell size Clinical BM infiltration by leukemia, resulting in anemia, thrombocytopenia, granulocytopenia, immune paralysis, ↓ B cells and CD4–helper T cells, ↑ CD8–suppressor T cells, infiltration and leukostasis, cranial nerve palsies, meningitis, lymphadenopathy, hepatosplenomegaly, testicular and cutaneous involvement, metabolic derangements–eg, ↑ Ca2+, K+, LD, ammonia, weight loss, less commonly, autoimmune hemolytic anemia, pallor and arthralgia Diagnosis Hx, physical exam, peripheral smear Management Chemotherapy, RT, BMT. See Accelerated leukemia, Acute leukemia, Acute lymphocytic leukemia, Acute myelocytic leukemia, Acute promyelocytic leukemia, Adult T-cell leukemia-lymphoma, Aleukemic leukemia, Biphenotypic leukemia, Central nervous system leukemia, Chemotherapy-induced leukemia, Chronic leukemia, Chronic lymphocytic leukemia, Chronic myelocytic leukemia, Chronic myelomonocytic leukemia, Congenital leukemia, Erythroleukemia, FAB classification, Hairy cell leukemia, Hand mirror cell leukemia, Herald state of leukemia, Mast cell leukemia, Megakaryoblastic leukemia, Multilineage leukemia, Plasma cell leukemia, Preleukemia, Prolymphocytic leukemia, Promyelocytic leukemia, Smoldering myeloid leukemia.
Leukemia Acute v. Chronic
Acute leukemia More common in children, 80% are ALL, often before age 10, peak at ages 3–7 in whites, ♂:♀ ratio, 1.3:1 Cell types Early pre-B cell 67%; pre-B cell 18%; B cell 1%; T cell 14%; 50-85% are cALLA positive–common acute lymphocytic leukemia antigen, CD10; 5% have Philadelphia chromosome Clinical ALL is more abrupt than AML, with petechial hemorrhage, bone and abdominal pain, headache and vomiting due to ↑ intracranial pressure, lymphadenopathy, splenomegaly, hepatomegaly Lab 70% have low-grade lymphocytosis–< 20 x 109 when diagnosed Evaluation Acute leukemia immunophenotypic profile Specimen EDTA–lavender top tube and sodium heparin–green top tube, peripheral blood smears Method of analysis Flow cytometry, immunofluorecesence Markers measured CD1, -2, -3, -4, -5, -7, -8, -10, -19. -20, -21, -33, -34, -56, megakaryocytic markers, HLA D/DR, kappa, lambda, TdT Management Protocols vary according to standard- or high-risk clinical features, and may include BMT
Chronic leukemia More common in adults/older children, often myelocytic; CML is Philadelphia chromosome positive; may occur < age 5 with myelomonocytosis, anemia, thrombocytopenia, lymphadenopathy; WBC count < 50 x 109, ≠ HbF, ≠ muraminidase; adult CML comprises 20% of all leukemias Clinical Gradual onset of fatigability, anorexia, splenomegaly; lymphadenopathy is uncommon Lab > 25 x 109/L leukemic cells in blood–often an absolute lymphocytosis of > 15 x 1010/L, < 10% blasts in BM, myeloid:erythroid ratio is 10-30:1, 90% of cases have low-to-absent leukocyte alkaline phosphatase and rarely also, ≠ vitamin B12 and B12-binding capacity Evaluation Chronic leukemia immunophenotype profile Specimen EDTA–lavender top tube and sodium heparin–green top tube, peripheral blood smears Method of analysis Flow cytometry, immunofluorescence Markers measured CD3, -5, -19, -20, -21, kappa, lambda Management see Chemotherapy, Induction Prognosis see Remission.
Leukemia–prognostic features
Acute lymphocytic leukemia
Good Age 2-10, CD10 positivity, hyperdiploid karyotype
Poor Age < 2; >10, B-cell phenotype, especially L2 phenotype by FAB classification, presence of chromosome translocations, CNS involvement, mediastinal masses, high initial WBC count
Acute myelocytic leukemia
Good Younger, presence of Auer rods, rapid therapeutic response
Poor Older, prior malignancy or therapy, multiple chromosome defects  
References in classic literature ?
He had built himself a country-seat within a few miles of his native town, and there spent such portions of his time as could be spared from public service in the display of every grace and virtue--as a newspaper phrased it, on the eve of an election--befitting the Christian, the good citizen, the horticulturist, and the gentleman.
This, indeed, was a home,--home,--a word that George had never yet known a meaning for; and a belief in God, and trust in his providence, began to encircle his heart, as, with a golden cloud of protection and confidence, dark, misanthropic, pining atheistic doubts, and fierce despair, melted away before the light of a living Gospel, breathed in living faces, preached by a thousand unconscious acts of love and good will, which, like the cup of cold water given in the name of a disciple, shall never lose their reward.
Speeches would be made, presents exchanged, and the audience would break up in universal good humor.
Now Heinel had found a friend in a good fairy, that was fond of him, and had told him what to do; for this fairy knew what good luck was in store for him.
The waggon had drawn up under the churchyard wall, in a spot screened from view, and the driver, nothing loth, soon hauled down the poor heap of household goods.
SOCRATES: And the goods which you mean are such as health and wealth and the possession of gold and silver, and having office and honour in the state--those are what you would call goods?
In the highest class, I replied,--among those goods which he who would be happy desires both for their own sake and for the sake of their results.
My next work was to view the country, and seek a proper place for my habitation, and where to stow my goods to secure them from whatever might happen.
So I got #50 in money paid me that same night, and made an end of the bargain; nor did he ever know who I was, or where to inquire for me, so that if it had been discovered that part of the goods were embezzled, he could have made no challenge upon me for it.
The young woman was glad of it also for the present occasion, though she had one, and so had the youth, on board our ship among their goods, which were not yet brought on shore.
Ogg's of having goods brought in their own and in foreign bottoms,--a subject on which Mr.
Jo heard that, but made no answer, except to kiss her mother, and walk rapidly away, thinking with a glow of gratitude, in spite of her heartache, "How good she is to me