Although most clinicians intuitively link the effect of GnRH agonists and antagonist on LH levels to that of FSH, the regulation of these two hormones in the anterior pituitary gonadotroph
cells by GnRH and other stimulus are very different.
21-23) Endogenous GnRH is released from the median eminence of the hypothalamus, binding to receptors on the gonadotroph
, and facilitating the production and secretion of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) into the systemic circulation.
tumors usually secrete their products inefficiently and in low concentrations and, thus, very rarely cause any clinical syndrome other than sellar mass effects (3), (4).
GnRH agonist may support the corpus luteum by stimulating the secretion of LH by pituitary gonadotroph
cells, direct effect on the embryo or by acting directly on the endometrium through locally expressed GnRH receptors.
Growth hormone-producing adenomas are associated with acromegaly and/or gigantism, prolactin-producing adenomas cause hyperprolactinemia and its clinical sequela, adrenocorticotropin-producing adenomas are associated with Cushing or Nelson syndromes, thyrotropin-producing tumors are associated with disturbances of thyroid function, and rare clinically detectable gonadotroph
adenomas usually result in hypogonadism.
In the new study, the researchers investigated by creating mice lacking insulin receptors only in the gonadotroph
Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph
Ultrastructural studies on the anterior pituitary confirmed the he prolonged and profuse action of the superactive analogue on the gonadotroph
Preservation of gonadotroph
function resulting in subsequent pregnancy has most often been reported in the literature (4).
cells of the pituitary secrete low amounts of hCG in men and women.
Effects of toxic levels of lead on gene regulation in the male axis: increase in messenger ribonucleic acids and intracellular stores of gonadotrophs
within the central nervous system.
Effects of an indigenous contraceptive herbal formulation on gonadotrophs
of the pituitary gland of the rat.