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gonadotoxic

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gonadotoxic /go·na·do·tox·ic/ (go-nad´ah-tok″sik) having a deleterious effect on the gonads, such as radiation or a chemotherapeutic agent.


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Chemotherapeutic agents and combination regimens vary in their impact on ovarian reserve, but generally speaking cyclophosphamide and doxorubicin have the greatest gonadotoxic effect.
Sex hormone production proceeds independently in the testicular Leydig's cells, which can tolerate higher cumulative doses of gonadotoxic therapy.
 
 
 
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