gonadotoxic

gonadotoxic

/go·na·do·tox·ic/ (go-nad´ah-tok″sik) having a deleterious effect on the gonads, such as radiation or a chemotherapeutic agent.
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Previous work had shown that up to 80% of women of reproductive age will have some ovarian function resume after treatment with gonadotoxic chemotherapy agents, said Ms.
Nowadays, massive efforts are being made to preserve fertility in young women exposed to gonadotoxic chemotherapy.
2) The potential negative gonadotoxic impact of treatments offered in childhood and adolescence have placed fertility preservation (FP) for children, adolescents, and young adults with cancer at the forefront of survivorship efforts.
As per the drug regimens used, COPP has been documented to be most gonadotoxic.
Ethics Committee of the American Society for Reproductive Medicine (2013), "Fertility Preservation and Reproduction in Patients Facing Gonadotoxic Therapies: A Committee Opinion," Fertility and Sterility 100(5): 1224-1231.
Assessment of toxicological and safety effects of pesticides is crucial because these chemicals pose adverse effects including infertility, cancer, gonadotoxic effects, fetal malformations and chromosomal aberrations (Ahmad et al.
Serum AMH is a sensitive biomarker for monitoring cancer chemotherapy and gonadotoxic treatment on ovarian follicular reserve of young women.
Finally, egg freezing was initially developed with the dual purposes of circumventing bans on the cryopreservation of embryos, as in the Italian case, and of providing an alternative to embryo storage for single women who were to undergo necessary medical procedures requiring removal of part of all of the reproductive organs or the use of gonadotoxic treatments like chemotherapy.
The present study is, therefore, designed to examine the effects of ribavirin on the morphometry of seminiferous tubules of testes in rats as an experimental model with the hope that the results of this study may pave the way for reassurance of a patient using this drug about the reversibility of its gonadotoxic effects on his fertility.
It is known, however, that many types of treatment used in Hodgkin's lymphoma or other hematological malignancies have a gonadotoxic effect (3).
These include carcinogenic, mutagenic, and teratogenic as well as gonadotoxic, embryotoxical, nefrotoxic and neurotoxic effects.
Environmental exposures, such as pesticides, may be gonadotoxic (Sigman & Jarow, 2007), and exposure to heat from sources, such as saunas and hot tubs, may elevate testicular temperatures, also impairing spermatogenesis (Procope, 1965; Sigman & Jarow, 2007).