gonadotoxic

gonadotoxic

/go·na·do·tox·ic/ (go-nad´ah-tok″sik) having a deleterious effect on the gonads, such as radiation or a chemotherapeutic agent.
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If the man has had exposure to any of the gonadotoxic agents (Table 1), he should be taken off these medications and his semen should be retested in 3 to 6 months.
The American College of Obstetricians and Gynecologists (ACOG) said in a January 2014 opinion that cryopreservation of oocytes should no longer be considered experimental for women facing infertility as a result of chemotherapy or other gonadotoxic therapies.
Serum AMH is a sensitive biomarker for monitoring cancer chemotherapy and gonadotoxic treatment on ovarian follicular reserve of young women.
It is known, however, that many types of treatment used in Hodgkin's lymphoma or other hematological malignancies have a gonadotoxic effect (3).
These include carcinogenic, mutagenic, and teratogenic as well as gonadotoxic, embryotoxical, nefrotoxic and neurotoxic effects.
These cytotoxic regimens are less gonadotoxic [4,5].
Chemotherapeutic agents and combination regimens vary in their impact on ovarian reserve, but generally speaking cyclophosphamide and doxorubicin have the greatest gonadotoxic effect.
The gonadotoxic effect of the varicocele may be progressive.
Sex hormone production proceeds independently in the testicular Leydig's cells, which can tolerate higher cumulative doses of gonadotoxic therapy.
Neurological and Renal Disturbances, Gonadotoxic and Mutagenic effects, Disturbance of Cholesterol metabolism.
This is especially true for women who may be receiving gonadotoxic therapies, such as alkylating agents or abdominal/pelvic radiation.