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Benign neoplasm composed of germ cells, sex cord derivatives, stromal cells; appears in cases of mixed or pure gonadal dysgenesis; usually small (1-3 cm) and partially calcified, but may give rise to malignant germ-cell tumors, most often seminoma/dysgerminoma or embryonal.
Etymology: Gk, gone, seed + blastos, germ + -oma, tumor
a rare benign type of germ cell tumor, usually occurring in patients with gonadal dysgenesis, and often bilateral. It contains all gonadal elements and is frequently associated with an abnormal chromosomal karyotype. It may give rise to a dysgerminoma or other more malignant germ cell tumor. See also dysgerminoma, gonadal dysgenesis.
gonadoblastomaGynecology Dysgenetic gonadoma A mixed germ cell-sex cord-stromal tumor which is most commonly seen in sexually abnormal persons, especially with gonadal dysgenesis–GD with a Y chromosome–ie, XY GD and XO-XY mosaicism; gonadoblastomas carry a 25% risk of neoplasia. See Sex-cord tumor Urology A mixed germ cell-sex cord-stromal tumor which almost invariably arises in a background of a gonadal disorder, either pure or mixed gonadal dysgenesis, male pseudohermaphroditism or, less commonly, in a phenotypically or karyotypically normal male. See Sex cord-stromal tumor.
Rare, benign neoplasm composed of germ cells, sex cord derivatives, and stromal cells; appears in cases of mixed or pure gonadal dysgenesis; usually small (1-3 cm) and partially calcified but may give rise to malignant germ-cell tumors, most often seminoma and dysgerminoma or embryonal; usually bilateral; found in patients with gonadal dysgenesis.
a rare, primary tumor of testicle or ovary containing, besides interstitial cells, germ cells, epithelial cells and granulosa cells.