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Related to goitrogens: goiter, goitre, hypothyroidism

goitrogens (goi´trōjenz),

n.pl the agents such as thiouracil and related antithyroid compounds that are capable of producing goiter.
References in periodicals archive ?
An additional 10-fold uncertainty factor addresses the limitations related to this study as well as the existence of other goitrogens in the environment.
An additional group was administered the goitrogen PTU (6-n-propyl-2-thiouracil; Sigma-Aldrich Chemicals GmbH, Steinheim, Germany), which served as a reference control for TH effects.
Contrary to the previous observations that smoking (both active and passive) is an important goitrogen (32), there was no difference in the incidence of active and passive smoking between goitrous children and controls in our study.
Goitrogens are so named because the lack of iodine can result in enlargement of the thyroid, a condition known as goiter.
Many goitrogens are generally members of the brassica family.
There are two types of goitrogens described, one type which interferes with iodine uptake by the thyroid gland and include thiocyanate and perchlorate, while the other type are substances which inhibits the thyroid organic binding and coupling i.
Other contributing factors include improper food preparation practices; poor knowledge of dietary requirements, especially for infants and young children, often stemming from feeding traditions and taboos; frequent infections which cause diarrhea and vomiting, especially harmful to infants and children; low bioavailability of micronutrients caused by anti-nutritional factors in ready-to-eat foods (for example phytates, oxalates, trypsin inhibitors, goitrogens, saponins and cyanogenic glycosides in some roots, tubers, legumes and cereals--these chelators can form complexes with divalent cations such as iron and zinc, inhibiting their absorption in the gastro-intestinal tract) [4,5].
As a result of exposure to goitrogens, including the addition of bromine to all baked goods, the amount of iodine needed to counteract the effects of these goitrogens has drastically increased.
There are no studies with individual measures of thyroid function and these goitrogens available in infants.
Despite the finding that PCBs uniformly reduce circulating levels of TH in experimental animals, PCBs do not exert effects in experimental animals that are fully consistent with experimentally produced hypothyroidism using goitrogens such as propylthiouracil (PTU).
Sheehan, reported in the June 2002 issue of EHP Supplements, suggest that soy isoflavones' ability to disrupt the thyroid depends on other factors such as iodine deficiency, other dietary goitrogens, and underlying thyroid dysfunction.