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A chronic enlargement of the thyroid gland, not due to a neoplasm, occurring endemically in some localities, especially regions where glaciation occurred and depleted the soil of iodine, and sporadically elsewhere.
Synonym(s): struma, goitre.
Synonym(s): struma, goitre.
[Fr. from L. guttur, throat]
goitreEnlargement of the THYROID GLAND from any cause. This may be due to overactivity of the gland in THYROTOXICOSIS, to HASHIMOTO'S THYROIDITIS, to infective thyroiditis, to DYSHORMONOGENESIS, to cancer of the gland or to iodine deficiency.
goitrean abnormal swelling of the neck due to enlargement of the thyroid gland. This may be because of a lack of iodine in the diet (simple goitre) or to overactivity of the gland (exophthalmic goitre).
goitrechronic, non-neoplastic enlargement of thyroid; more common in women than men; due to autoimmune thyroid disease and inflammation, iodine deficiency, dyshormonogenesis, drugs (sulphonylurea agents, carbimazole)
enlargement of the thyroid gland, causing a swelling in the front part of the neck.
multilobular goiters cause thyroid enlargement in cats.
is characterized by the presence of a large soft thyroid gland with its glandular space distended with colloid. Most cases occur in neonatal lambs, calves and kids which show a high rate of stillbirths and weakness and a high mortality rate. Enlarged thyroid glands and alopecia are good indicants of the existence of a nutritional deficiency of iodine, the usual cause of goiter in animals.
an impairment in thyroglobulin synthesis is thought to be the cause of inherited, congenital goiter recorded in sheep, cattle and goats. The thyroid gland is enlarged, there is a high neonatal mortality, a silky wool in sheep and a rough, sparse haircoat in goats. Called also inherited goiter.
there are a number of goitrogens in the environment of grazing animals. Their effect is almost entirely on the newborn. Common agents are low level intakes of cyanogenetic glycosides, e.g. in white clover, the glucosinolates in Brassica spp. plants, and mimosine in Leucaena leucocephala.
diffuse hyperplasia is the standard response to dietary iodine deficiency and to poisoning by plant goitrogens. It may also be caused by persistent exposure of the fetus to a high iodine intake of the dam. See also iodide goiter (below). Neonates are the usual subjects and the disease is manifested by clinical goiter, often sufficient to cause dystocia, and weak neonates with a high rate of stillbirths and deaths soon after birth.
see dyshormonogenetic goiter (above).
that occurring in reaction to iodides at high concentrations, due to inhibition of iodide organification.
an endocrinologically inactive nodular enlargement of the thyroids in old dogs and horses. In old cats similar goiters sometimes develop functional adenomas.