gnotobiotic


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gno·to·bi·ot·ic

(nō'tō-bī-ot'ik),
Denoting germ-free or formerly germ-free organisms in which the composition of any associated microbial flora, if present, is fully defined.
[see gnotobiota]

gnotobiotic

[nō′tōbī·ot′ik]
pertaining to a germ-free animal or an animal or an environment in which all the microorganisms are known. See also germ-free animal.

gnotobiotic

Biology
adjective Referring to a system to which only preselected components, organisms and nutrients are introduced. Gnotobiotic organisms are either experimental models (e.g., mice with naïve immune systems), or “experiments of nature”, in which the natural immune defence is grossly defective (e.g., severe combined immune deficiency); prolonged survival of the host requires complete avoidance of exposure to pathogens.

gno·to·bi·ot·ic

(nō'tō-bī-ot'ik)
Denoting germ-free or formerly germ-free organisms in which the composition of any associated microbial flora, if present, is fully defined.

gnotobiotic

literally ‘known life’; typically referring to an environment or animal that is essentially germ-(microorganism-) free, or one in which the microbial flora present is known, usually because it has been deliberately introduced.

gnotobiotic

pertaining to a gnotobiote or to gnotobiotics.

gnotobiotic animal
one that has been born germ free and then infected with known microorganisms. See also axenic and specific pathogen free.
References in periodicals archive ?
Epithelial attachment and other factors controlling the colonization of the intestine of the gnotobiotic chicken by lactobacilli.
When the distal gut microbiota from young, conventionally-reared mice were transplanted into the gnotobiotic mice, a 60% increase in body fat within 2 weeks was observed, without any increase in food consumption or energy expenditure.
Table 1: Effect of isolated PGPRs (plant growth-promoting rhizobacterias) on maize root growth and IAA production in Gnotobiotic study (Growth Pouch Study) Bacterial Experiment Incubation Time (h) Strains Detail 24 48 72 96 Control IAA Conc.
Pathogenesis of a genogroup II human norovirus in gnotobiotic pigs.
Similarly, the E1 strain of Ruminococcus gnavus, a strict anaerobic resident in the gut, has been shown to produce ruminococccin A, an antibacterial substance that actively prevents colonization by a range of pathogenic clostridia in experiments involving gnotobiotic rats (29,30).
Preliminary data in the gnotobiotic piglet model of Helicobacter pylori is very encouraging," says Dr.
In addition, gnotobiotic model organisms provide unique opportunities to study host-microbiota interplay with a level of experimental control that is not achievable in human studies.
Her primary research interest is the use of a gnotobiotic pig model to focus on viral epidemiology, vaccine development, gut microbiome and probiotic effects on immunity, and innate immune responses to enteric viral infections.
Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice.
Effects of age and diet on small intestinal structure and function in gnotobiotic piglets.
He says appropriate venues for doing the necessary additional research include gnotobiotic mouse models--that is, mice tightly controlled to contain only known microbial communities--anaerobic/aerobic cell cultures, and possibly human studies.
Scanning electron microscopy of trachea and bronchi from gnotobiotic pigs inoculated with Mycoplasma hyopneumoniae.